Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

203 > Endocrinology Of Age > Flashcards

Endocrinology Of Age Flashcards

1
Q

Sarcopaenia?

A

Loss of skeletal muscle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Lean body mass decline

A

6-8% from mid 30s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Metabolic syndrome includes?

A

Visceral obesity
Dyslipidaemia
Hyperglycaemia
Hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Post menopausal oestrogen levels?

A

E2 is low, high LH and FSH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

HRT Risks?

A

Other risk factors Venous thromboembolism, breast cancer (especially over 5 years use), endometrial cancer (unopposed oestrogen)

Age.. more than 60
More than 10 years post mp
Type of HRT and route

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Most erectile dysfunction is due to?

A

Atherosclerotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Potential risks of testosterone treatment?

A

Prostrate hypertrophy/cancer, erthyropoesis so increase risk of thrombosis and increased MI and strokes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Bone treatment?

A

Biphosphonates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Growth hormone treatment risk?

A

Increasing Cancer risk in increasing IGF1 levels, T2Dm

Side effects: oedema, arthralgias and carpal tunnel syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Increased cortisol possibly causes?

A

Cognitive decline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Low DHEA: cortisol conditions?

A

Inflammatory disease, cancer, T2D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Thyroid function in age?

A

Low T3, same t4 and slightly high TSH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Leptin is produced by?

A

White adipose tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Low leptin levels?

A

Increased food intake and decreased energy expenditure, low fertility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What symptoms do menopausal women experience?

A

Hot flushes and night sweats

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Testosterone levels at 75years is…?

A

2/3 of that at 25 years of age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Clinical hypogonadism signs in men?

A

Decreased sexual function
Increased osteoporosis
And decreased muscle strength

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Effects of T4 treatment?

A

Increasing risk of osteoporosis, atrial fibrillation and risk in elderly with atherosclerotic corona roes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Low leptin levels mean?

A

Increase food intake, decrease energy expenditure and decrease in fertility

20
Q

In starvation what happens to hormone levels?

A

Low LH, FSH, Low oestrogen and testosterone. Low fertility and amenorrhoea

21
Q

Obese and hyperphagic mouse mean?

A

Low gonadotrophin, incomplete development of reproductive organs, doesn’t reach sexual maturity and infertile

22
Q

How does kisspeptin work?

A

Mediated by leptin and highly responsive to oestrogen

23
Q

What happens in starvation and anorexia in terms of growth hormone?

A

Growth hormones increase and IGF1 decrease, may be due to down regulation of hepatic GH receptors or post receptor defect

Can be reversible with refeeding

24
Q

In fasting cortisol levels?

A

Peak

25
Q

In starvation what happens to thyroid functions?

A

TSH and T4 levels are lower. Less conversion of T4 to T3 and more conversion of T4 into T3 inactive form

26
Q

In starvation changes in thyroid hormones cause?

A

Lower basal metabolic rate and conserving energy

27
Q

When does weight plateau?

A

50-70

28
Q

Age of menopause?

A

50 +- 2

29
Q

Median duration of menopause symptoms?

A

7 years

30
Q

At 75. Years testosterone is what than at 25 years?

A

2/3

31
Q

Insulin like growth factor 1 with age?

A

Decreases

32
Q

T4 treatment can cause harm by?

A

Risk of oestoporosis, atrial fibrillation, and increased risk of atherosclerotic coronaries in elderly

33
Q

In AN hormones are?

A

Low LH and FSh, low oestorgen and testosterone, hypothalamic amenorrhoea

34
Q

Age at menopause?

A

50 plus or minus 2 years

35
Q

Growth hormone treatment can?

A

Increase lean body mass by 2kg
And decrease fat mass by 2 kg
No change in bone mineral density and lipids

36
Q

Potential harm with T4 treatment?

A

Increased risk of osteoporosis, atrial fibrillation and atherosclerotic coronaries

37
Q

In starvation?

A

Decreased glucose, insulin and increased leptin sensitivity

38
Q

Starvation and androgens?

A

Low LH and FSH and oestrogen and testosterone, low fertility amenorrhoea
Osteoporosis

39
Q

Oh ob mouse?

A 
Hyper-Hamid and obese
Low gonadotrophin
Incomplete development of reproductive organs 
Doesn’t reach sexual maturity
Infertile
40
Q

Giving leptin treatment?

A 
Reduce obesity
Restore gn secretion 
Mature gonad 
Induced puberty
Restore fertility
41
Q

Kisspeptin is?

A

A GnRH secratgogue, highly responsive to oestrogen

Mediated by leptin

42
Q

In starvation what happen to growth hormone?

A

Increases, and insulin like growth factor 1 decreases

43
Q

In starvation thyrolic rate oid function?

A

TSH and T4 lower limit of normal

Less T4 conversion to T3
More t4 conversion to rT3

Consequences: conserve energy
Lower basal metabolic

44
Q

What increases with age?

A 
Cortisol
FSH LH
TSH
Glucose 
Insulin
45
Q

What increases with starvation?

A

GH

cortisol

203 (74 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions