Endometrial Hyperplasia and CA Flashcards Preview

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Flashcards in Endometrial Hyperplasia and CA Deck (25):
1

what is the relationship between endometrial thickness and risk of endometrial CA?

increased thickness increases risk

2

t or f: endometrial hyperplasia is considered a precancerous condition

TRUE

3

which type of endometrial hyperplasia has the highest likelihood of professing to CA?

complex atypical hyperplasia (noting that atypical hyperplasia is more likely to progress to CA in older women than in those younger)

4

what is the gold standard diagnostic test for endometrial CA?

biopsy of the endometrium

5

women with this syndrome have a 40-60% lifetime risk of developing endometrial CA which is equal to their risk of developing colorectal CA

Lynch Syndrome (hereditoary nonpolyposis colorectal CA)

6

what are some of the side effects of progestin?

WTHEH: weight gain, thrombophlebitis, headache, edema, HTN

7

t or f: endometrial CA is the most gynecologic CA in the US

TRUE : should be followed by cervical and then ovarian

8

t or f: endometrial CA is often diagnosed in its early stages

TRUE - it often presents with obvious symptoms

9

what are the two types of endometrial CA? which is more common?

type I (more common) - dependent on estrogen that begins as proliferation of normal tissue; type II is unrelated to estrogen or hyperplasia and and tends to present both as higher grade and more aggressive

10

what is the mainstay of treatment for mostly all the different types of endometrial hyperplasia?

cyclical progestin therapy; it progresses to continuous progestin as the severity increases and eventual hysterectomy if need be.

11

which symptom is present 90% of the time for endometrial CA?

abnormal bleeding

12

t or f: pap smears are diagnostic for endometrial CA

FALSE

13

what are some differential diagnoses for endometrial CA?

endometrial hyperplasia, exogenous estrogen, endometrial polyps/cervical polyps, coagulopathy.

14

t or f: liver disease is a risk factor for endometrial CA?

TRUE (b/c a healthy liver is thought to be able to metabolize estrogens)

15

what are some risk factors for endometrial CA?

obesity, early menarche/late menopause, PCOS, DM, HTN, tamoxifen tx for breast CA

16

what is the diagnostic TOC for evaluation of post menopausal bleeding?

endometrial biopsy and D&C hysteroscopy of bx is not adequate

17

of what histologic subtype are most endometrial cancers?

endometroid

18

t or f: hyperplasia without atypia has the same risk of progressive to CA as hyperplasia with atypia

FALSE: much lower without atypia

19

how is endometrial CA staged?

clinically (and again, as the stages increase in number the more widespread/invasive the CA is)

20

what is the most important prognosticator in endometrial CA?

grade

21

in comparison to G1, is G3 more or less well differentiated?

LESS (IOW, poorly differentiated)

22

what is the basic treatment for all stages of endometrial CA?

TAH, BSO

23

adjuvant chemo includes doxorubicin and cisplatin - what are some common side effects of these drugs?

dox: cardiotoxicity; cis: nephrotoxicity

24

pt presents with rapidly enlarging mass with bleeding - what's the diagnosis?

VERY RARE - but uterine sarcoma (less than 1% of fibroids progress to CA)

25

t or f: leiomyosarcomas are approx. 1/3 of all uterine sarcomas

TRUE