Endometrium & Myometrium Pathology

Question 1

Endometrium ?

Answer 1

Mucosal lining of the uterine cavity

pathoma-141

Question 2

Myometrium ?

Answer 2

Smooth muscle underlying the endomatrium

Question 3

Endometrium is hormone sensitive ?

Answer 3

1. Growth = Estrogen = Proliferative phase
2. Preparation = Progesterone = Secretory phase
3. Shedding = Loss of Progesterone = Menstrual phase

Question 4

Secondary amenorrhea is called ?

Answer 4

Asherman syndrome

Question 4

Asherman syndrome cause ?

Answer 4

1. Loss of basalis
2. Loss of scarring

Question 5

Loss of ovulation is called —

Answer 5

Anovulatory cycle

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Question 6

Result of anovulatory phase ?

Answer 6

Estrogen driven proliferative phase
without progesterone driven secretrory phase (X)

Question 7

Anovulatory cycle represents —-

Answer 7

Dysfunctional uterine bleeding

Question 8

Bacterial infection of the endometrium is called ?

Answer 8

Acute endometritis

Question 9

Presentation of acute endometritis ?

Answer 9

1. Fever
2. Pelvic pain
3. Abnormal uterine bleeding

Question 10

Acute endometritis cause ?

Answer 10

1. Retained products of conception
2. After delivery or miscarriage
3. Retained products acts as a nidus for infection

Question 11

Chronic inflammation of the endometirum is called >?

Answer 11

Chronic endometirits

Question 12

Presentation of chronic endometritis ?

Answer 12

1. Abnormal uterine bleeding
2. Infertility
3. Pain

Question 13

Characteristics of chronic endometritis ?

Answer 13

1. Plasma cell’
2. Lymphocytes

Question 14

Dx of chronic endometrosis ?

Answer 14

Plasma cell

Question 15

Causes of CE ?

Answer 15

1. IUD
2. TB
3. Retained products of conception
4. Chronic pelvic inflammatory disease
5. Chlamydia

Question 16

Hyperplastic protrusion of endometrium —

Answer 16

Endometrial polyp

Question 17

Cause of which drug is E Polyp ?

Answer 17

Tamoxifen

Question 18

Presenattion of endometrial polyp ?

Answer 18

Abnormal uterine bleeding

Question 19

Tamoxifen drug >?

Answer 19

Anti estrogenic effects

Question 20

Endometrial glands and stroma outside the uterine endometrial lining ?

Answer 20

Endometriosis

Question 21

Endometriosis presentation ?

Answer 21

1. Dysmenorrhea - Pain + Menstruation
2. Pelvic pain
3. Infertility

Question 22

Endometriosis causes ?

Answer 22

1. Retrograde menstruation
2. Implantation at an ectopic site

Question 23

Most common site of endometriosis?

Answer 23

Ovary

Question 24

Implants in endometriosis presentation ---

Answer 24

Gun powder nodules

Question 24

Ovary fate in endometriosis?

Answer 24

Chocolate cyst

Question 25

Endometriosis + Uterine myometrium =

Answer 25

Adenpmyosis

Question 26

Sites and Effects of endometriosis?

Answer 26

1. Uterine ligament = Pelvic pain 2. Pouch of douglas= Pain + Defecation 3. Bladder = Pain + Urination 4. Bowel serosa = Ab Pain + Adhesion 5. Fallopian tube mucosa = Ectopic tubal pregnancy + Scarring | PATHOMA-142

Question 27

Hyperplasia of endometrial flands + Stroma =

Answer 27

Endometrial hyperplasia

Question 28

Casues of EH ?

Answer 28

1. Obesity 2. Tamoxifen 3. Estrogen replacement 4. Polycystic ovary syndrome

Question 28

Maliganant proliferation of endometrial glands ?

Answer 28

Endometrial cancer

Question 28

Pathways of endometrial canceer ????

Answer 28

1. Hyperplasia pathway- 75% 2. Sporadic pathway -25%

Question 28

Presentation of EH ??

Answer 28

Postmenopausal uterine bleeding

Question 29

Risk of Ca in EH ?

Answer 29

Single hyperplasia + Atypia

Question 30

Estrogen dependent pathway ?

Answer 30

Hyperplasia pathway

Question 30

Risk factor of hyperplasia E Ca ?

Answer 30

1. Menarche 2. Late menopause 3. Nullipority 4. Infertility 5. Obesity

Question 31

Sporadic pathway Histo Presentation?

Answer 31

1. Serous 2. Papillary structure 3. Psammoma bodies 4. p53 Mutation

Question 32

Presentation of leiomyoma ?

Answer 32

1. Abnormal uterine bleeding 2. Pelvic mass 3. Infertility

Question 32

Benign neoplastic proliferation of smooth muc=scle ?

Answer 32

Leiomyoma/Fibroids

Question 33

Common exposre ?

Answer 33

1. Premenopausal women 2. Often multiple 3. Enlarge during preganancy 4. Shrink after meenopasue

Question 34

Leiomyosarcoma gross -

Answer 34

1. Single lesion 2. Necrosis 3. Hemorrhage

Question 34

Gross exam of fibroids ?

Answer 34

1. Multiple 2. Well defined 3. White 4. Whorled masses 5. may dirtort the uterus 6. Impinge on pelvic structures

Question 35

Maliganant proliferate of smooth muscle

Answer 35

Leiomyosarcoma

Question 36

Leiomyosarcoma histo ?

Answer 36

1. Necrosis 2. Mitotic activity 3. Cellular atypia | Pathoma-144