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Flashcards in Enteric 1 and 2 Deck (12):

Picornaviruses, noroviruses, and rotaviruses are all

small, nake, icosahedral RNA viruses. Enteroviruses are the subset of picornavirses that cause GI infection


Rotavirus has a

segmented genome, causes potentially-dangerous dehydrating diarrhea


Norovirus is extremely

contagious, low infectious dose, short hard bout of vomiting and diarrhea


Enteroviruses do their main replication in

the gut, but also cause viremia with replication in regional lymp nodes and can rarely penetrate the CNS, thus infection is usually mild but occasionally devastating


Noroviruses, rotaviruses, and enteroviruses are all

widespread worldwide, though the course of the disease in the first world is substantially attenuated by hygiene and vaccination


REN are environmentally

rugged, allowing for fecal-oral transmission


REN can cause

self-limited GI illness, usually resolving without medical intervention or complication. Most common complications are dehydration w/ roto (watch for pediatric anorexia and lethargy), CNS infection with enteroviruses


Most of the problematic enteric virus infections are

pediatric; the younger, the WORSE. Coxsackie B is 10% lethal in neonates


Coxsackie A symptoms (_____________) are usually

herpangina, AHC, HFMD;
less severe than Coxsackie B (myocarditis, pleurodynia, meningitis), but there is overlap



vesicles on those three plus inside the diaper. Herpangina: ulcerating vesicles inside mouth. Pleurodynia: severe intermittent chest pain with pleural fiction rub


What can be used to isolate the virus/and or detect its RNA?

Use LP, nasopharyngeal swabs, and/or stool culture; some serologic tests are available


Watch literature for

new approvals/contraindications for Pleconaril; all other care is supportive: rehydrate, rest, treat complications