Enterobacteriacae Flashcards Preview

Term 4: Infectious Diseases > Enterobacteriacae > Flashcards

Flashcards in Enterobacteriacae Deck (54):
1

What is MacConkey agar?

-contains bile salts to suppress the growth of most gram (+) organisms

-suppresses growth of Neisseria & Haemophilus

-also contains lactose & a pH indicator

2

What type of agar plates do we use to test lactose fermentation in Gm (-) organisms?

MacConkey agar

3

Which surface antigen on Gm (-) organisms confers motility?

Flagella

(H Antigen)

4

What do fibriae do for Gm (-) bacteria?

-allows attachment to host cell

-exhibit phase variation

(used for UTI)

5

What does it mean if bacteria can form a biofilm?

-they have a capsule

6

Why can't organisms that have lipooligosaccharide grow in the gut?

-sensitive to bile salts

7

What infection is caused by bacteria with P-fimbriae?

Pyelonephritis

8

What does LPS do to the host?

Activates the sepsis cascade

9

What are siderophores?

-allow Gm (-) bacteria to scavenge Fe from environment

-Gm (-) bacteria need iron to live

10

What is the K antigen a part of?

-the gram (-) capsule

11

What diseases are caused by Klebsiella?

-UTI

-Pneumonia

-multiple nosocomia infections (biliary infection, peritonitis, wound infxn)

12

When are Morganella and Providencia infections seen?

-individuals with long-term catheters

*very close cousins of Proteus

13

What diseases are caused by Proteus mirabilis?

-UTI

-Staghorn calculus

14

What diseases are caused by Citrobacter?

-Catheter associated UTI

-Brain abscess in neonates

15

What mediates adhesion of E. Coli to intestinal mucosa?

Fimbriae (Pili)

16

In what organism do we see Hemolytic uremia syndrome (HUS)?

-Enterohemorrhagic E. Coli (EHEC)

-Shigella

17

What are the three components of Hemolytic uremic syndrome?

-Renal failure

-Hemolytic anemia

-Thrombocytopenia

18

Pt has renal failure, hemolytic anemia, and thrombocytopenia. What organism are we thinking?

-Enterohemorrhagic E. Coli (EHEC)

-Shigella

* these are the components of Hemolytic uremic syndrome, seen in EHEC infection

19

What diseases are caused by Enteropathogenic E. Coli (EPEC)?

-acute diarrhea in infants

20

What diseases does Enteroaggregative E. Coli (EAEC) cause?

-chronic diarrhea & malnutrition in developing countries

-#2 travelers diarrhea

21

How do we identify Enteroaggregative E. Coli (EAEC)?

stacked brick adherence to tissue culture cells in Hep-2 cell assay

22

What diseases are caused by Enteroinvasive E. Coli?

diarrhea

23

E. coli only causes neonatal meningitis if it has ________.

K antigen

24

E. coli's heat Labile toxin increases c_MP.

cAMP

25

E. coli's heat Stable toxin increases c_MP levels.

cGMP

26

Lactose fermenters turn _________ on mackonkey agar.

Pink

27

What infections are caused by klebsiella?

-lobar pneumonia

-UTI

28

To treat klebsiella you need to use _________ because all klebsiella are ampicillin resistant.

B lactamase inhibitors

29

Is serratia a normal part of the human fecal flora?

no

30

A disk approximation test is used to see if there is ________ in __________ (bacteria).

-induced resistance

-Enterobacter

31

Some subtypes of Enterobacter express a _______ in response to certain antibiotics.

B-lactamase

32

"swarming on blood agar"

Proteus

33

What is the treatment for proteus?

Sulfonamides

34

Biggest worry about citrobacter?

Brain abscesses

35

What are the 2 bugs that cause enteric fever?

-salmonella

-yersinia

36

Which strain of E. coli is the most common cause of outbreaks of bloody diarrhea?

O157:H7 EHEC

37

"LEE pathogenecity island"

STEC & EHEC

38

Antibiotics are contraindicated in diarrhea caused by _______, becuase it will cause a massive release in toxins, resulting in HUS.

EHEC

39

Shiga toxin binds to the ________ portion of ribosomes, and inhibits translation.

60s

40

How do people get infected with Shigella?

Ass-to-mouth

41

Why is the infectious dose of Shigella super low? (10-100 organisms)

It is acid-stable

42

What are the virulence factors of Shigella?

-Invasive (more important) uses actin to propel itself

-Shiga toxin

43

Shigella causes HUS more commonly in _________.

young children

44

How are shigella and Listeria similar?

-Both invade M cells

-Both use Host's actin to propel themselves

45

Salmonella is (motile/non-motile), while Shigella is (motile/non-motile).

Salmonella = motile

Shigella = non-motile

46

_________ is the #1 cause of osteomyelitis in patients with sickle cell.

Salmonella typhi

47

This diarrhea causing bug is carried by reptiles and amphibians.

Salmonella 

48

"Rose colored macules"

Salmonella typhi

49

Salmonells _______ likes to live in the gallbladder.

Salmonella typhi

50

Recurrent salmonella is an _____-defining illness.

AIDS

51

Yersinia enterocolitica is commonly transfered via _______.

Puppy poop

52

Yersinia doesn't make _________.  Thus, iron overload is a risk factor for infection.

Siderophores

53

Disease caused by Yersinia is exacerbated by _________.

abscence of a spleen, or sickle cell

54

Infection with this bug causes RLQ pain, and is often indistinguishable from acute appendicitis.

Yersinia enterocolitica