Flashcards in Bacterial Structure & Function Deck (14)
What does TLR 5 sense?
Which TLR's can sense ss/ds RNA/DNA of viruses and bacteria?
TLR 3, 7, 8, 9
Which TLR's sense various membrane/wall components of gram + bacteria, mycobacteria, and yeast?
TLR 1, 2, 6
What is the structure of gram-negative bacteria?
Contain an inner membrane, surrounded by a thin cell wall that is encompassed by an outer membrane
What is the structure of gram-positive bacteria?
-single membrane surrounded by a thick cell wall
What is the mechanism of action of Vancomycin?
-it binds to C-terminal D-Ala-D-Ala of late peptidoglycan (gram +) precursors
-prevents reactions catalyzed by transglycosylases, transpeptidases, and the D,D-carboxypeptidases
How does LPS act as an endotoxin?
-in the bloodstream it can contribute to sever immune response resulting in septic shock
What portion of LPS can be modified to resist cationic peptide antibiotics?
-Lipid A moiety
What are the three main moieties of LPS?
What is flagellin?
-the protein that makes up the filament portion of the flagellum
-ligand for TLR5
What are the 5 common molecular targets of antibiotics in bacteria?
What is a metatranscriptome?
-a collection of genes expressed in an environment
What is a pan-genome?
-a set of genes found in a particular bacterial species