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EoN 2.0 > Enzymer nukleotidmetabolism > Flashcards

Enzymer nukleotidmetabolism Flashcards

1
Q

PRPP-syntas

A

Ribos 5 P —> 5-fosforibosyl-1-pyrufosfat

Purinsyntes
Magnesium
ATP –> AMP

Defekt i PRPP-syntas —> ingen feedback hämning –> ökad purinsyntes –> primär gikt.

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2
Q

APRT

A

Adenin fosforibosyltransferas

Adenin + PRPP –> AMP

Salvage

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3
Q

HGPRT

A

Hypoxantin Guanin fosforibosyltransferas

Guanin, Hypoxantin + PRPP –> GMP, IMP

Salvage

Lesh Nyhans syndrom.
( ökad de novo syntes av puriner) —> urinsyra ansamlas. PRIMÄR GIKT.

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4
Q

CPS 2

A

Carbamoylfosfatsyntas 2

Glutamin —> glutamat

NH3 + Co2 –> karbamoylfosfat

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5
Q

Ribonukletoidreduktas

A

xDP —> dxDP

FADH2
NADH

2 allosteriska sites

Sjukdom SCID
Vi kan inte bryta ner AMP (ADA= adensoindeaminas)

Förskjuts till dATP —> hämmar ribonukleotidreduktas —> ingen bildning av DNA

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6
Q

Thymidylatsyntas

A

dUMP —> dTMP

5 fluoracil kemoterapi.

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7
Q

Adenosindeaminas

A

AMP –> inosin

dATP samlas, hämmar ribonukleotidreduktas

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EoN 2.0 (21 decks)

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