epilepsy Flashcards

(37 cards)

1
Q

what is a seizure

A

it is the abnormal electrical discharge in the brain causing symptomatic manifestations
one seizure is not epilepsy but is an indication for investigations

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2
Q

what is epilepsy

A

it is when there are recurrent seizures

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3
Q

what is the recurrence rate of seizures after one year

A

70%

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4
Q

Epidemiology

A

life time risk of seizures is 5%

prevelance of seizure is 0.5%

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5
Q

Types of seizures

A

Generalised - involves both hemispheres simultaneously

Focal (partial) - activity is limited to one part of the cortex

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6
Q

Epilepsy starting age 35 and over usually are?

A

focal cerebral event

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7
Q

what can one tell from the symptoms and signs of a seizure

A

one can predict the region of brain affected

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8
Q

causes seizures

A
Idiopathic
Genetic - tuberous sclerosis
developmental
Neoplastic (brain tumour)
traumatic (head injury)
infective
inflammatory (vasculitis)
benzodiazepine withdrawl
metabolic - hypernatraemia, hypocalcaemia, ureamia, glucose fluctuations
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9
Q

What happens before a Tonic-Clonic seizure

A

Aura

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10
Q

What happens during a Tonic-Clonic seizure

A

Px goes rigid then stops breathing, cyanosed and LOC and may fall heavily
after few minutes rigidity relaxed and starts clonic jerks
Urinary incontinence or tongue biting may occur

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11
Q

What happens after a Tonic-Clonic seizure

A

Px regains consoiusness but is confused and drowsy

headaches are common

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12
Q

what happens in absence seizures

A

always start in childhood
child goes blank and stares for few seconds only and then continue as normal
maybe speaking a sentences then stops for few seconds <10s and then continue where left off
Px do not relies it is happening to them but may have many per day.

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13
Q

what absence seizure could be mistaken for

A

daydreaming

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14
Q

Myoclonic seizures Sx

A

Brief jerking movements usually in arms

occur in the morning or upon waking

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15
Q

what provokes myoclonic seizures

A

alcohol
fatigue
sleep deprivation

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16
Q

Atonic seizures Sx

A

Atonic (opposite tonic) Px briefly losses muscle tone and becomes flacid and floppy.

17
Q

what can atonic seizures result in

A

heavy falls with or without LOC

18
Q

Tonic seizures

A

Px has generalised increased muscle tone and is associated with LOC

19
Q

Clonic seizures

A

Aura
tonic clonic jerks
may urinary incontinence or tongue biting
afterwards drowsy and confused

20
Q

What is an aura

A
strange feeling in gut
flashing lights
strange smells
deja vu
usually before neuro event
21
Q

What investigations should be carried after a seizures

A
Head CT or MRI
Electroencephalography (EEG)
Full bloods
HIV
CXR
syphilis serology
CSF
22
Q

types of focal (partial) seizures

A

simple partial seizures - no LOC

complex partial seizure - with LOC –> suggests temporal lobe involvement

23
Q

causes of seizures by age groups

A

children and teenagers - genetic and congenital disorders

younger adults - trauma drugs and alcohol

elderly >60 cerebrovascular events and neoplasms

24
Q

Lifestyle management of seizures

A

Advice on work and risk prevention
Caution if work involves driving, heights, machinery, fires or water
legal restrictions on driving

25
first line drug Rx for focal seizures or secondary generalised tonic-clonic seizures (GTCS)
Lamotrigine
26
second line drug Rx for focal seizures or secondary GTCS
``` Carbamazepine Levetiracetam Sodium valproate Topiramate Zonisamide ```
27
1st line for GTCS
Sodium valproate | Levetiracetam
28
2nd line for GTCS
Lamotrigine Topiramate Zonisamide
29
1st line absence
Ethosuximide
30
2nd line absence
Sodium valproate
31
1st line myoclonic
Sodium valproate
32
2nd line myoclonic
Levetiracetam | Clonazepam
33
when is surgery indicated
when seizures are drug resistant
34
when should sodium valproate be prevented
in F of reproductive age unless benefits outweigh risks
35
What should you as a clinicion be aiming when giving drug Rx for seizures
use as few and simple doses as possible | ideally one drug
36
When drug withdrawal can be considered?
after 2 seizure free years gradual withdrawal can be considered
37
What is secondary GTCS
starts off as a simple seizures and evolves into a GTCS | starts with no LOC then becomes LOC and convulsions