Erythroblastosis Fatalis Flashcards
What is erythroblastosis fatales?
(hemolytic disease of newborn and fetus)
Maternal destruction of fetal RBC by IgG.
Which antibodies cause erythroblastosis fatalis?
Kell (kills), Kidd (kills), Duffy (FyA) (dies)
Which antibodies do NOT cause erythroblastosis fatalis?
Lewis, I, Duffy (fyb)
What is the most common cause of hemolytic disease of newborn?
ABO incompatibility (1%).
Presents as neonatal jaundice due to a Coombs positive hemolytic anemia.
Infrequent unlike Rh sensitization, which can occur intrauterine.
ABO incompatilbiltiy does NOT cause hydrops bc anti-A and anti-B Ab are IgM and don’t cross placenta.
What is aneuploidy risk at maternal age 30?
Down’s: 1/1000
Any chromosomal abnormality: 1/500
What is aneuploidy risk at maternal age 35?
Down’s: 1/365
Any chromosomal abnormality: 1/180
What is aneuploidy risk at maternal age 40?
Down’s: 1/100
Any chromosomal abnormality: 1/50
What is aneuploidy risk at maternal age 45
Down’s: 1/36
Any chromosomal abnormality: 1/18
What crosses placenta by simple diffusion
Oxygen, Co2, electrolytes, ketones
What crosses placenta by active transport?
Amino acids, calcium, phosphorus, iron
What crosses the placenta by facilitated diffusion?
sugars! sucrose, glucose, fructose
What crosses placenta by endocytosis?
IgG
What crosses placenta by bulk flow vs. carrier mediated?
bulk flow: water
carrier: iodine
What crosses the placenta?
PTU, TRH, iodine, magnesium sulfate, IgG, Propranolol, T3, T4
What does NOT cross the placenta?
Tyrosine, Triiodothyronine, Insulin, Heparin, TSH, glucagon, Prednisone
