Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

HEMATOLOGY 1 > erythropoiesis > Flashcards

erythropoiesis Flashcards

(92 cards)

Start Studying
1
Q

process of RBC FORMATION TAKESS PLACE INSIDE THEE BONE MARROW

A

ERYTHROPOIESIS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

TOTAL MASS OF RBCS CIRCULATING IN THE PERIPHERAL BLOOD ADN THE BONE MARROW RBC PRECURSOR

A

ERYTHRON

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ERYTHROCYTES IN THE CIRCULATION

A

RBC MASS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

A TERM THAT DESCRIBE THE DYNAMICS OF RBC CREATION AND DESTRUCTION

A

ERYTHROKINETICS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

PRODUCTION OF DEFEECTIVE ERYTHROID PRECUSOR

A

INFFECTIVE ERYTHROPOIESIS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

EXAMPLES OF CONDITIONS OF INEFFECTIVE ERYTHROPOIESIS

A

VITAMIN B12 DEFICIENCY
FOLATE DEFICIENCY
THALASSEMIA
SIDEROBALSTIC ANEMIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

DECREASE IN THE NUMBER OF RBC PRECURSOR IN THE BONE MARROW

A

INSUFFICIENT ERYTHROPOIESIS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

EXAMPLES CONDITIONS OF INSUFFICIENT ERYTHROPOIESIS

A

IRON DEFICIENCY ANEMIA
RENAL DISEASE
ACUTE LEUKEMIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

IMMATURE HEMTAPOIETIC CELL THAT IS COMMITTED TO A CELL LINE BUT CANNOT BE IDENTIFIED MORPHOLOGICALLY

A

PROGENITOR CELLS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

IMMATURE HEMATOPOIETIC CELL. THAT IS MORPHOLOGICALLY IDENTIFIABLE AS BLEONGING TO GIVEN CELL LINE

A

PRECURSOR CELLS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

EARLIEST MARKER OF ERYTHROID PRECURSOR AND TRANSFERRIN RECEPTOR

A

CD71

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

EXAMPLES OF HORMONE RELATED TO ERYTHROPOIESIS

A

EPO
GROWTH HORMONE
TESTOSTERONE
PROLACTIN.
ESTROGEN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CHIEF STIMULATOR CYTOKINE FOR RBC

A

EPO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

MAJOR HORMONE THATT STMULATES THE PRODUCTION OF RBC

A

EPO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

PRIMARY CELL SOURCE OF EPO

A

PERITUBULAR INTERSTITIAL CELL (KIDNEY

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

PRIMARY TARGET OF EPO

A

BFU-E AND CFU-E

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

NORMMALLY EPO ISS RELEASED FROM THE KIDNEY INTOO THE BLOOD IN RESPONSE TO ___

A

HYPOXIA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

TRANSPORT PROTEIN OF IRON IN THE BLOOD

A

TRANSFERRIN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

EPO SIME OF THE CURRENT./ POTENTIAL THERAPEUTIC APPLICATIONS

A

ANEMIA OF CHRONIC RENAL DISEASE
AUTOLOGOUS PREDOMINATION BLOOD COLLECTION
ANEMIA IN HIV INFECTION TO PERMIT USE OF AZT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

PRODUCED BY. PITUITARY GLAND
STIMULATES ERYTHROPOIESIS DIRECTLY

A

GROWTH HORMONE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

PRODUCED BY TESTES AND STIMULATES ERYTHROPOIESIS INDIRECTLY

___—> KIDNEYS—> EPO—> BM—> RBC

A

TESTOSTERONE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

PRODUCED BY PITUITARY GLAND THAT STIMULATES ERYTHROPOIESIS DIRECTLY

A

PROLACTIN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

PRODUCED BY OVARIES THAT INHIBITS ERYTHROPOIESIS INDIRECTLY

A

ESTROGEN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

EARLIEST COMMITTED PROGENITOR

A

BFU-E

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
2 COMMITTED ERYTHROID PROGENITOR CELLS
BFU-E (BURST- FORMING UNIT- ERYTHROID) AND CFU-E (COLONY FORMING UNIT- ERYTHROID)
26
HOW MANY WEEK/S FROM BFU-E TO CFU-E
1 WEEK
27
HW MANY WEEK/S FROM CFU-E TO RUBRIBLAST
1 WEEK
28
IT TAKES ABOUT ___ FOR THE BFU-E TO MATURE AND ERYTHROCYTE OF WHICH APPROXIMATELY ___ ARE SPENT RECOGNIZABLE PRECURSOR IN THE B,
18-21 DAYS 6 DAYS
29
ERWER
30
EXAMPLES OF SUPRAVITAL STAIN USED TO DEMONSTRATION OF RETICULOCYTES
BCB (BRILLIANT VRESYL BLUE) NMB (NEW METHYLENE BLUE)
31
WHEN RETICULOCYTE COUNT ARE FOUND IN A WRIGHT STAIN SMEAR THEY ARE CALLED
POLYCHROMATOPHILIC ERYTHROCYTES DIFFUSELY BASOPHILIC ERYTHROCYTE
32
MORPHOLOGICAL FEATURES USED TOO IDNTIFY ANS TAGE RBC AND WBC PRECURSOR
NC RATIO
33
PERTAINS TO THE BLUENESS OF A PARTICULAR PART OF THE CELL AND IS DUE TO THE ACIDIC COMPONENT THAT ATTRACT BASIC STAIN
BASOPHILIA
34
PERTAINS TO THE PINKNESS OF A PARTICULAR PART OF THE CELL AND IS DUE. TO THE ACCUMULATION OF MORE BASIC COMPONNETS THAT ATTRACT THE ACID STAIN EOSIN
EOSINOPHILIA
35
EARLIEST RECOGNIZABLE ERYTHROID PRECURSOR USING THE LIGHT MICROSCOPE
RUBRIBLAST
36
COARSER CHROMATIN ABSENCE OF NUCLEOLI LAST STAGE WITH NUCLEOLI ADN 1 STAGE OF HB SYNTHESIS
PRORUBRICYTE
37
LAST STAGE CAPABLE OF MITOSIS 1ST STAGE IN WHICH THE CYTOPLASM IS PINKK
RUBRICYTE
38
NUCLEUS IS EXTRUDED AT THIS STAGE AND THE CELL BECEAOMES A RETICULOCYTE LAST STAGE WITH NUCLEUS
METARUBRICYTE
39
LAST STAGE OF HEMOGLOBIN SYNTHESIS
RETICULOCYTE
40
HOW MANY DAYS DOES THE RETICULOCYTE SPENDS IN THE BONE MARROW
2 TO 3 DAYS
41
HOW MANY DAYS DOES THE RETICULOCYTE SPENDS IN PERIPHERAL BLOOD
1 DAY
42
WHAT IS THE SHAPE OF RETICULOCYTE IN THE ELECTRON MICROGRAPHS
IRREGULAR
43
NUMBER OF ERYTHROCYTE PRODUCED FROM EACH RUBRIBLAST
8-32
44
NORMAL RATIO OF RBC TO WBC
600:1
45
NORMAL RATIO OF RBCS TO PLATELET
15:1
46
AVERAGE LIFE SPAN OF RBC
120 DAYS
47
ENVELOPED EXTRUDED NUCLEUS ENGUKFED BY BONE MARROW MACROPHAGE
PYRENOCYTE
48
RUBRICYTE OR LYMPHOCYTE NUCLEUS IS CHECKER BOARD COLOR OF CYTOPLASM IS MUDDY OR GRAY
RUBRICYTE
49
RUBRICYTE OR LYMPHOCYTE NUCLEUS IS CRUSHED VELVET COLOR OF CYTOPLASM IS SKY BLUE OR RONAN BLUE
LYMPHOCYTE
50
RUBRIBLAST GIVES RISE TO ____ PRORUBRICYTES
2
51
THE PRORUBRICYTE GIVES RISE TO _____
4 RUBRICYTE
52
WHAT ARE THE RBC MEMBRANE CONSTITUENTS
8% CARBOHYDRATES 40% LIPIDS 52% PROTEINS
53
ALSO PROVIDE THE VERTICAL SUPPORT CONNECTING THE LIPID BILAYER TO TEH UNDERLYING CYTOSKELETON TO MAINTAIN MEMBRANE INTEGRITY
TRANSMEMBRANE PROTEIN
54
EXAMPLES OF TRANSMEMBRANE PROTIEN
AQUAPORIN 1 BADN 3 CA 2+ ATPase duffy GLUT 1 GLYCOPHORIN A GLYCOPHORIN B GLYCOPHORIN C ICAM 4 KELL KIDD RH RHAG
55
FX OF THS TRANSMEMBRANE PROTEIN IS WATER TRANSPORTER
AQUAPORIN 1
56
FX OF THS TRANSMEMBRANE PROTEIN IS ANION TRANSPORTER AND SUPPORT ABH ANTIGENS
BAND 3
57
FX OF THS TRANSMEMBRANE PROTEIN IS CA2+ TRANSPORTER
CA2+ ATAPASE
58
FX OF THS TRANSMEMBRANE PROTEIN SUPPORT DUFFY ANTIGENS
DUFFY
59
FX OF THS TRANSMEMBRANE PROTEIN GLUCOSE TRANSPORTER, SUPPORT ABH ANTIGEN
GLUT-1
60
FX OF THS TRANSMEMBRANE PROTEIN TRANSPORT NEGATIVELY CHARGED SIALIC ACID, SUPPORTS DETERMINANTS
GLYCOPHORIN A
61
FX OF THS TRANSMEMBRANE PROTEIN TRANSPORT NEGATIVELY CHARGED SIALIC AICD SUPPORT SS DETERINANTS
GLYCOPHORIN B
62
FX OF THS TRANSMEMBRANE PROTEIN TRANSPORT NEGATIVELY CHARGED SIALIC ACID SUPPORTS GERBICH SYSTEM DETERMINANTS
GLYCOPHORIN C
63
FX OF THS TRANSMEMBRANE PROTEIN INTEGRIN ADHESION
ICAM 4
64
FX OF THS TRANSMEMBRANE PROTEIN ZN 2+ BINDING ENDOPEPTIDASE, KELL ANTIGENS
KELL
65
FX OF THS TRANSMEMBRANE PROTEIN UREA TRANSPORTER
KIDD
66
D AND CcEe ANTIGENS
RH
67
NECESSARY FOR THE EXPRESSION OF D AND CcEe GAS TRANSPORTER PROBABLY CO2
RHAG
68
PROVIDE THE HORIZONTAL OR LATERAL SUPPORT FOR THHE MEMBRANE THE SHAPE FLEXIBILITY OF THE RBC DEPENDS ON THE SYTOSKLETOON
SKELETAL PROTEINS
69
PRIMARY CYTOSKELETAL PROTEINS
ALPHA SPECTRIN BETA SPECTRIN
70
DEFECT N PROTEIN THAT DISTURBS VERTICAL MEMBRANE INTERACTIONS BETWEEN TRANSMEMBRANE PROTEINS AND UNDERLYING CYTOSKELTON LOSS OF MEMBRANE AND DECREASED SURFACE AREA TO VOLUME RATIO
HEREDITARY SPHEROCYTOSIS
71
SOLUTION FOR PX WITH SPHEROCYTE
SPLENECTOMY
72
MOST SENSITIVE AND SPECIFC TEST TO CONFIRM THE DIAGOSIS OF HS
EMA BINDING TEST
73
DEFECT IN PROTEINS THAT DISRUPT THE HORIZONTAL-LINKAGES IN THE PROTEIN CCYTOSKELTON LOSS OF MECHANICAL STABILITY OF MEMBRANE
HEREDITARY ELLIPTOCYTOSIS
74
SEVERE DEFECT IN SPECTRIN THAT DISRUPTS HORIZONTAL LINKAGES IN PROTEIN CYTOSKLETON; SEVERE RBC FRAGMENTATION
HEREDITARY PYROPOIKILOCYTOSIS
75
DEFECT IN BAND 3 CAUSING INCREASED MEMBRANE RIGIDITY; RESISTANT TO MALARIA AND PREVALENT. IN SOME ARE OF SOUTHEAST ASIA
HEREDITARY OVALOCYTOSIS
76
INCREASED MEMBRANE PERMIABILITY TO SODIUM AND POTASSIUM INCREASED INTRACELLULAR SODIUM CAUSING INFLUC OF WATER INCREASE IN CELL VLUME AND DECREASED CYTOPLASMIC VISCOSITY DEFICIENT IN RHAG
OVERHYDRATED HEREDITARY STOMATOCYTOSIS
77
INCREASED MEMBRANE PERMEABILITY TO POTASSIUM; DECREASED INTRACELLULAR POTASSIUM RESULTING IN LOSS OF WATER FROM CELL DECREASE IN CELL VOLUME, ADN INCREASED CYTOPLASMIC VISCOSITY
HEREDITARY XEROCYTOSIS
78
TYPICAL RBC MORPHOLOGY FOR OVERHYDRATED HEREDITARY STOMATOCYTOSIS
STOMATOCYTE MACRCYTES
79
TYPICAL RBC MORPHOLOGY FOR DEHYDRATED HEREDITARY STOMATOCYTOSIS
TARGET CELL BURR CELLS STOMATOCYTE
80
RBCS WITH PUDDLED” HEOGLOBIN AT PERIPHERY DESSICIATED CELLS WITH SPICULES
DEHYDRATED HEREDITARY STOMATOCYTOSIS
81
MUTATIONS THAT CHANGE MEMBRANE STRUCTURES
HEREDITARY SPHEROCYTOSIS HEREDITARY ELLIPTOCYTOSIS HEREDITARY OVALOCYTOSIS
82
( DISEASES)MUTATIONS THAT CHANGES MEMBRANE TRANSPORT PROTEIN
OVERHYDRATED HEREDITARY STOMATOCYTOSIS DEHYDRATED HEREDITARY STOMATOCYTOSIS
83
RARELY DONE BECAUSE OF INACCURACY AND QUESTIONABLE NECESSITY
MANUAL RBC COUNT
84
RBC COUNT, HEMOGLOBIN AND HEMATOCIRT VALUES ARE___ IN PEOPLE LIVING AT A HIGHEER ALTITUDE VER WHAT. THEY WOULD BE AT SEA LVEL
ELEVATED
85
THE HB IS ITHE DIFFERENCE OF VALUES IN HIGHER ALTITUDE IS
1g/hb/dl at 2km altitude 2g. hb/dl
86
MAJOR GLYCOLYTIC OPATHWAY IN RBC
EMBDEN-MEYERHOF PATHWAY
87
HOW MANY. ATP DOES EMBDEN MEYERHOF PATHWAY PRODUCE
2
88
MOST COMMON ENZYME DEFICIENCY OF THE EMP AND IS THE MOST COMMON FORM OF HEREDITARY NONSPHEROCYTIC HEMOLYTIC ANEMIA
PK DEFICIIENCY
89
POSSIBLE PBS FINDING INCLUDES IN PK DEFICIENCY
ACANTHOCYTES ADN BURR CELL
90
RECOMMENDED SCREENING TEST FOR PK DEFICIENCY
PK FLUORESCENT SPOT TEST
91
SCREENING TEST FOR PK DEFICIENCY
AUTPHEMOLYSIS TEST
92
CONFIRMATORY TEST FOR PK DEFICIENCY
QUANTITATIVE PK ASSAY

HEMATOLOGY 1 (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions