Exam 1 Koh- Cornea Biochem 1 Flashcards Preview

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Flashcards in Exam 1 Koh- Cornea Biochem 1 Deck (80)
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31

What is Bowman's layer secreted by?

Anterior stromal keratocytes and epithelium

32

What happens when there is damage to Bowman's layer?

Scarring

33

What are the cellular components of the basal lamina?

Collagen types IV, VII, IX and XVI, fibronectin, heparan sulfate

34

What types of proteoglycans are in the stroma?

Keratan sulfate, dermatan sulfate, chondroitan sulfate

35

What types of collagen are in the stroma?

Types I and VI (major) and types III and V (minor)

36

What are the cellular components of Descemet's membrane?

Collagen- types IV and VIII, laminin fibronectin

37

What is the most abundant protein in the body?

Collagen

38

What is type I tissue in?

Skin, bone, tendon, BV, cornea

39

What is type II tissue in?

Cartilage, intervertebral disk, vitreous body

40

What is type III tissue in?

Blood vessels, fetal skin

41

What is type IV tissue in?

Basement membrane

42

What is type VII tissue in?

Beneath stratified squamous epithelia

43

What is type IV tissue in?

Cartilage

44

What are the fibril forming collagens?

I, II, III

45

What are the network-forming collagens?

IV, VII

46

What are the fibril-associated collagens?

IX

47

Which collagens have a rope-like structure?

Fibrillar collagens

48

Which collagens form a 3D mesh?

Network forming collagens

49

Collagen is rich in ____ and ____ important in the formation of the triple-stranded helix

Proline and glycine

50

What is hydroxylation?

Maximizes interchain H bonds and stabilizes the triple helix

51

The polypeptide precursors of the collagen molecule are formed in ______ and are secreted into ____ ____

Fibroblasts, extracellular matrix

52

What is the breakdown of collagen fibrils dependent on?

Proteolytic action of collagenases, which are a part of a large family of matrix metalloproteinases

53

Normal collagens are highly ____ molecules

Stable

54

Osteogenesis Imperfecta

Brittle bone syndrome, this disease is a consequence of decreased production of alpha 1 and alpha 2 chains

55

The stroma is what percentage of the corneal thickness?

90

56

How many layers of lamallae are in the stroma?

200

57

Lamellae

Collagen fibrils enmeshed in a matrix (proteoglycans, proteins, and glycoproteins)

58

What types of collagen are in the stroma?

I, V, VI, VII, XII, XIV, III

59

What type of collagen is associated with stromal wound healing?

III

60

What is the most abundant heteropolysaccarides in the body?

GAGs