Flashcards in Exam 1 Koh- Cornea Biochem 1 Deck (80)
Loading flashcards...
31
What is Bowman's layer secreted by?
Anterior stromal keratocytes and epithelium
32
What happens when there is damage to Bowman's layer?
Scarring
33
What are the cellular components of the basal lamina?
Collagen types IV, VII, IX and XVI, fibronectin, heparan sulfate
34
What types of proteoglycans are in the stroma?
Keratan sulfate, dermatan sulfate, chondroitan sulfate
35
What types of collagen are in the stroma?
Types I and VI (major) and types III and V (minor)
36
What are the cellular components of Descemet's membrane?
Collagen- types IV and VIII, laminin fibronectin
37
What is the most abundant protein in the body?
Collagen
38
What is type I tissue in?
Skin, bone, tendon, BV, cornea
39
What is type II tissue in?
Cartilage, intervertebral disk, vitreous body
40
What is type III tissue in?
Blood vessels, fetal skin
41
What is type IV tissue in?
Basement membrane
42
What is type VII tissue in?
Beneath stratified squamous epithelia
43
What is type IV tissue in?
Cartilage
44
What are the fibril forming collagens?
I, II, III
45
What are the network-forming collagens?
IV, VII
46
What are the fibril-associated collagens?
IX
47
Which collagens have a rope-like structure?
Fibrillar collagens
48
Which collagens form a 3D mesh?
Network forming collagens
49
Collagen is rich in ____ and ____ important in the formation of the triple-stranded helix
Proline and glycine
50
What is hydroxylation?
Maximizes interchain H bonds and stabilizes the triple helix
51
The polypeptide precursors of the collagen molecule are formed in ______ and are secreted into ____ ____
Fibroblasts, extracellular matrix
52
What is the breakdown of collagen fibrils dependent on?
Proteolytic action of collagenases, which are a part of a large family of matrix metalloproteinases
53
Normal collagens are highly ____ molecules
Stable
54
Osteogenesis Imperfecta
Brittle bone syndrome, this disease is a consequence of decreased production of alpha 1 and alpha 2 chains
55
The stroma is what percentage of the corneal thickness?
90
56
How many layers of lamallae are in the stroma?
200
57
Lamellae
Collagen fibrils enmeshed in a matrix (proteoglycans, proteins, and glycoproteins)
58
What types of collagen are in the stroma?
I, V, VI, VII, XII, XIV, III
59
What type of collagen is associated with stromal wound healing?
III
60
