Exam 2 Notes Flashcards
(62 cards)
Metabolism
sum of the catabolic (break down, hydrolysis. This is Krebs cycle) and anabolic (building, condensation reactions. This is photosynthesis) reactions in the body
1st law of thermo
energy is neither created nor destroyed. Energy is transformed in reactions; some is lost as heat.
2nd law of thermo
to find the total energy (enthalpy), it is usable (free energy usually 10%) + unusable (usually 90%. Is called entropy, often is heat) energy times the absolute temperature.
delta H= delta G + Delta S(T)
free energy (delta g)
Free energy is spontaneity (whether a reaction is spontaneous or not. -ve is spontaneous)
Total energy example (enthalpy)
as ATP is hydrolyzed by ATPase, some energy is released. Some is gone to move sodium and potassium and the other is usable
food chains are really short
because only 10% of energy gets transferred every time!
*Hayden has that problem IF YOU FORGET
Exergonic
energy being released
endergonic
energy is moving in
work
release energy that can be put into another system to create work. ex. is the pumps that regulate salt and water balances
enzymes
are protein catalysts
irreversible inhibition
nonpermanent binding and has a high affinity. it will not let go of the enzyme
reversible inhibition types
competitive and noncompetitive
competitive
substance has a lower affinity for the enzyme and will compete
noncompetitive
binds to the allosteric site and will change shape of the active site
think about the enzyme graph
lesson 9
don’t forget about the high energy intermediate
induced fit
enzyme hugs the substrate
allosteric site
another site on the enzyme
sodium potassium pump
will bring in 2 potassium and send out three sodium
hemoglobin
has 4 subunits and there are 2 alpha myoglobins and 2 betas (is a quaternary structure) that are opposite each other (X)
The cofactor is iron 2+ in each alpha and beta myoglobin (oxygen binds to the iron)
Cofactor: inorganic, has no carbon (can be a metal)
Prosthetic group: no amino acids in this, but it can be organic gives better stability and structure. Heme does this (made of iron and other stuff)
coenzyme
is organic, it has nonpermanent binding. Basically moves stuff around for an enzyme to bind to the substrate. Hemoglobin does not have a coenzyme
go draw hemoglobin
please
where does each metabolic process occur in mitochondria
matrix is where the Krebs is
cytoplasm is glycolysis
ETC is in the inner membrane/intermembrane space
ethanol and lactate have how many carbons?
2
totals for GRABOWSKI”s metabolic cycle?
24 ATP and 2 GTP
18 from NADH
4 from FADH
2 ATP glycolysis
2 GTP from Krebs