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AU14 Drug Mechanisms > Exam 3; Mechanisms > Flashcards

Exam 3; Mechanisms Flashcards

1
Q

quinidine

A

anti-arrhythimic (Class Ia)

Na+ channel blocker

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2
Q

procainamide

A

anti-arrhythimic (Class Ia)

Na+ channel blocker

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3
Q

disopyramide

A

anti-arrhythimic (Class Ia)

Na+ channel blocker

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4
Q

lidocaine

A

anti-arrhythimic (Class Ib)

Na+ channel blocker

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5
Q

mexiletine

A

anti-arrhythimic (Class Ib)

Na+ channel blocker

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6
Q

metoprolol

A

anti-arrhythmic (Class II)

beta 1 blocker

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7
Q

propranolol

A

anti-arrhythmic (Class II)

beta 1 blocker

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8
Q

esmolol

A

anti-arrhythmic (Class II)

beta 1 blocker

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9
Q

sotalol

A

anti-arrhythmic (Class III)

K+ channel blocker, beta 1 blocker

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10
Q

amiodarone

A

anti-arrhythmic (Class III)

All four! Na+ channel blocker, beta 1 blocker, K+ channel blocker, Ca++ channel blocker

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11
Q

dronedarone

A

anti-arrhythmic (Class III)

All four! Na+ channel blocker, beta 1 blocker, K+ channel blocker, Ca++ channel blocker

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12
Q

verapamil

A

anti-arrhythmic (Class IV)

Ca++ channel blocker

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13
Q

diltiazem

A

anti-arrhythmic (Class IV)

Ca++ channel blocker

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14
Q

nifedipine

A

anti-arrhythmic (Class IV)

Ca++ channel blocker

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15
Q

adenosine

A

anti-arrhythmic

binds to adenosine receptor, decreasing firing rate of AV node

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16
Q

GTN (glyceryl trinitrate)

A

aka nitroglycerin
treats angina
activates NO –> guanylate cyclase

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17
Q

isosorbide dinitrate

A

treats angina

activates NO –> guanylate cyclase

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18
Q

digoxin

A

treats CHF, inotropic

inhibits Na+-K+-ATPase

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19
Q

dobutamine

A

treats CHF, inotropic

beta 1 agonist

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20
Q

tadalafil

A 
treats ED
inhibits enzyme (Type 5 cGMP phosphodiesterase)
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21
Q

varedenafil

A 
treats ED
inhibits enzyme (Type 5 cGMP phosphodiesterase)
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22
Q

avanafil

A 
treats ED
inhibits enzyme (Type 5 cGMP phosphodiesterase)
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23
Q

sildenafil

A 
treats ED
inhibits enzyme (Type 5 cGMP phosphodiesterase)
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24
Q

alprostadil

A

treats ED

injectable prostaglandin E1

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25
citric acid
anti-coagulant | Ca++ chelator
26
EDTA
anti-coagulant | Ca++ chelator
27
EGTA
anti-coagulant | Ca++ chelator
28
heparin
anti-coagulant | activates anti-thrombin
29
dalteparin
anti-coagulant | activates anti-thrombin
30
enoxaparin
anti-coagulant | activates anti-thrombin
31
fondaparinux
anti-coagulant | activates anti-thrombin
32
hirudin
anti-coagulant | inhibits thrombin
33
bivalirudin
anti-coagulant | inhibits thrombin
34
desirudin
anti-coagulant | inhibits thrombin
35
argatroban
anti-coagulant | inhibits thrombin
36
warfarin
oral anti-coagulant | inhibits enzyme that recycles/resynthesizes vitamin K
37
dabigatran
oral anticoagulant | inhibits thrombin directly
38
rivaroxaban
oral anticoagulant | inhibits factor Xa
39
apixaban
oral anticoagulant | inhibits factor Xa
40
vorapaxar
platelet inhibitor | thrombin receptor blocker
41
ticagrelor
platelet inhibitor | ADP receptor blocker
42
ticlopidine
platelet inhibitor | ADP receptor blocker
43
prasugrel
platelet inhibitor | ADP receptor blocker
44
clopidogrel
platelet inhibitor | ADP receptor blocker
45
abciximab
platelet inhibitor | fibrinogen receptor blocker
46
eptifibatide
platelet inhibitor | fibrinogen receptor blocker
47
tirofiban
platelet inhibitor | fibrinogen receptor blocker
48
aspirin
platelet inhibitor COX enzyme inhibitor (inhibits TXA2 synthesis)
49
cilostazol
platelet inhibitor | phoshodiesterase enzyme inhibitor
50
dipyridamole
platelet inhibitor | phoshodiesterase enzyme inhibitor
51
anagrelide
platelet count reducer
52
TPA = tissue plasminogen activator
thrombolytic agent | convert plasminogen --> plasmin
53
streptokinase
thrombolytic agent | convert plasminogen --> plasmin
54
urokinase
thrombolytic agent | convert plasminogen --> plasmi
55
aminocaproic acid
hemostatic agent | inhibit plasminogen activation
56
tranexamic acid
hemostatic agent | inhibit plasminogen activation
57
epoietin alfa
to treat anemias due to chronic renal failure or chemotherapy erythropoietin agent
58
peginesatide
to treat anemias due to chronic renal failure or chemotherapy erythropoietin agent
59
darbepoietin
to treat anemias due to chronic renal failure or chemotherapy erythropoietin agent
60
hydroxyurea
to treat sickle cell anemia | inc formation of fetal hemoglobin
61
"statin"s
hypolipidemic agent best to dec LDL inhibits HMG-CoA reductase enzyme
62
niacin
hypolipidemic agent aka vitamin B3, nicotinic acid best to inc HDL inhibits enzyme + binds receptor
63
coleseleuam
hypolipidemic agent | bile acid binding resin --> excret cholesterol
64
colestipol
hypolipidemic agent | bile acid binding resin --> excret cholesterol
65
cholestyramine
hypolipidemic agent | bile acid binding resin --> excret cholesterol
66
gemfibrozil
fibrates, hypolipidemic agent best to dec triglycerides bind PPAR (activating receptor) --> inc lipoprotein lipase
67
fenofibrate
fibrates, hypolipidemic agent best to dec triglycerides bind PPAR (activating receptor) --> inc lipoprotein lipase
68
icosapent ethyl
fish oil, hypolipidemic agent | inhibits enzyme --> dec triglyceride synthesis
69
omega 3 fatty acids
fish oil, hypolipidemic agent | inhibits enzyme --> dec triglyceride synthesis
70
lomitapide
hypolipidemic agent enzyme and transporter inhibits VLDL assembly in liver
71
mipomersen
hypolipidemic agent | binds mRNA for apolipoprotein --> prevents APO synthesis
72
ezetimibe
hypolipidemic agent | blocks chol transporters in gut --> dec chol absorption
73
sitostanol
hypolipidemic agent | blocks chol uptake (looks like chol)
74
orlistat
hypolipidemic agent | inhibits GI + pancreatic lipase enzymes
75
olestra
hypolipidemic agent | oil is not absorbable

AU14 Drug Mechanisms (7 decks)

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