Exam 3: Nervous System Development III Flashcards Preview

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Flashcards in Exam 3: Nervous System Development III Deck (20):
1

What areas of the brain have additional gray matter on top of the white matter tracts?

Cerebrum & cerebellum

2

A true _____ consists of multiple layers of gray matter and is built from the inside out.

Cortex

3

_____ _____ cells are located in the ventricular zone and extend all the way to the surface of the brain.

Radial glial

4

Abnormalities of radial glial cells in the cerebellum causing abnormal migration and granular layering is called?

Weaver

5

Abnormal/absence of cortical layering is due to _____.

Reeler

6

What protein has been shown to be defective in Reeler mutant mice?

Reelin

7

GET SOMEONE TO SEND YOU BOX 11.1

GET SOMEONE TO SEND YOU BOX 11.1

8

Pronounced expansion of the roof plate to form the thin roof over the 4th ventricle is the major topographical change of the _____.

Myelencephalon

9

Expression of which genes is responsible for differentiation of specific nuclei in the myelencephalon?

Hox genes

10

What are the major derivatives of the metencephalon?

Pons & cerebellum

11

Induction of the roof plate and neural tube via BMP signaling in the metencephalon causes the _____ to form in the region of the _____ _____.

Cerebellum.
Rhombic lips

12

What are massive fiber bundles between the cerebellum & mesencephalon?

Superior cerebellar peduncles.

13

_____ cells migrate anteriorly along dorsal region of rhombomere 1 and interiorly through the purkinje layer.

Granule

14

_____ cells migrate radially through granule cells.

Purkinje

15

What are the major derivatives of the alar plates of the mesencephalon?

Superior/inferior colliculi

16

What confines Shh to the basal part of the midbrain?

Otx-2

17

What is the function of cerebral peduncles?

Carry fibers between hemispheres & spinal cord

18

What are the 3 patterning centers in the forebrain and what signal molecules are involved with them?

Rostral: FGF-8
Dorsal: BMPs & Wnts
Ventral: Shh

19

What is a closure feature of the spinal cord called?

Rachischisis

20

Closure defects can be diagnosed by elevated levels of _____ in the amniotic fluid.

Alpha-fetoprotein