Exam 3: Nucleotides And Nucleic Acids Flashcards by Rachel Smith

Q

Committed step in purine synthesis

A

PRPP to 5 phosphoribosylamine

GPAT

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Q

Source of ribose 5 phosphate for nucleotide synthesis

A

PPP

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Q

2 time methyl donor during purine synthesis

A

THF

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Q

Nucleoside

A

Base + sugar

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Q

Nucleotide

A

Base + sugar + phosphate

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Q

Purines

A

G

A

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Q

Pyrimidines

A

T
C
U

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Q

Nucleotides made 2 ways

A

De novo synthesis

Salvage

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Q

Salvage is preferred because

A

Less ATP is needed

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Q

3 things needed for de novo synthesis

A

ATP
Ribose 5 phosphate
PRPP

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Q

___ used in both purine and pyrimidine synthesis

A

PRPP

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Q

PRPP synthetase reaction

A

Ribose 5P —> PRPP

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Q

GPAT reaction

A

PRPP —> 5 phosphoribosylamine

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Q

Steps using ATP in purine synthesis

A

3, 5, 6

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Q

Steps adding C’s in purine synthesis

A

4, 7

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Q

THF

Study These Flashcards

A

Tetrahydrofolate

Q

Inadequate folate during pregnancy can cause

Study These Flashcards

A

Neural tube defects

Q

___ is precursor to other purine Nucleotides

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A

IMP

Q

IMP is precursor to

Study These Flashcards

A

AMP
GMP
Hypoxanthine base

Q

Enzymes that use THF

Study These Flashcards

A

GAR synthetase

AICAR formyltransferase
Adenylosuccinate lyase

Q

___ inhibits GPAT

Study These Flashcards

A

Hypoxanthine

Q

Salvage pathway uses ____ to inhibit GPAT

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A

Hypoxanthine

Q

Hypoxanthine + PRPP =

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A

IMP

Q

Xanthine —> uric acid

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A

Xanthine oxidase

Xanthine oxidase inhibited by

Allopurinal

Allopurinal treatment for

Gout

Gout

Increase in uric acid that can accumulate in soft tissues

IMP to adenylosuccinate

Adenylosuccinate synthetase

Adenylosuccinate to AMP

Adenylosuccinate lyase

IMP to XMP

IMP DH

XMP to GMP

GMP synthetase

Nucleotides degraded to

Nucleotides

Nucleosides degraded to

Free bases

Free bases degraded to

Common base (xanthine)