Glycolysis Flashcards Preview

Biochemistry II > Glycolysis > Flashcards

Flashcards in Glycolysis Deck (45):
1

First step enzyme

Hexokinase

2

First step reactant and product

Glucose —- glucose 6 phosphate

3

2nd step enzyme

Phosphoglucose isomerase

4

2nd step product and reactant

Glucose 6 phosphate —- fructose 6 phosphate

5

3rd step enzyme

PFK

Phosphofructokinase

6

3rd step reactant and product

Fructose 6 phosphate —- fructose 1,6 bisphospate

7

Irreversible steps in glycolysis

1
3
10

8

Rate limiting step in glycolysis

Step 3

(PFK1)

9

In first half of glycolysis, ATP is used in steps ___ and ___

1
3

10

Step 4 enzyme

Aldolase

11

Step 4 reactant and product

Fructose 1,6 bisphosphate —- glyceraldehyde 3 phosphate and dihydroxyacetone phosphate

12

Step 5 enzyme

Triose phosphate isomerase

13

Step 5 reactant and product

Dihydroxyacetone phosphate —- glyceraldehyde 3 phosphate

14

One glucose yields ___ pyruvates

2

15

In second half of glycolysis, all reactions happen ___ times

2

16

Step 6 enzyme

G3P dehydrogenase

17

Step 6 reactant and product

Glyceraldehyde 3 phosphate

1, 3 Bisphosphoglycerate

18

Step 7 enzyme

Phosphoglycerate kinase

19

Step 7 reactant and product

1, 3 bisphosphoglycerate

3-phosphoglycerate

20

Step 8 enzyme

Phosphoglycerate mutase

21

Step 8 reactant and product

3- phosphoglycerate

2-phosphoglycerate

22

Step 9 enzyme

Enolase

23

Step 9 reactant and product

2- phosphoglycerate

Phosphoenolpyruvate

24

Step 10 enzyme

Pyruvate kinase

25

Step 10 reactant and product

Phosphoenolpyruvate

Pyruvate

26

ATP used in steps __ and second half of glycolysis

7
10

27

NAD+ reduced to NADH in step ___

6 ( G3P dehydrogenase)

28

Water released in step

9 (dehydration via enolase)

29

Other sugars that can enter glycolysis

Sucrose (glucose + fructose)

Lactose (glucose + galactose)

30

Fructose enters glycolysis as

DHAP
Glyceraldehyde 3 phosphate
Hexokinase can convert fructose to fructose6-P

31

Galactose enters glycolysis as

Glucose 6 phosphate

32

Key enzymes of glycolysis

Hexokinase
PFK
Pyruvate kinase

33

Inhibitors of PFK1

ATP
Low pH
Citrate

34

Inhibition of PFK inhibits

Hexokinase

35

Hexokinase in liver and beta cells of pancreas

Glucokinase

36

Pyruvate kinase stimulated by

Fructose 1,6 phosphate

37

Alanine inhibits

Pyruvate kinase

38

Glucagon

Hormone secreted by pancreas when blood glucose is low

39

Glucagon objective

Elevate blood glucose

Inhibit glycolysis
Inhibit glycogen synthesis

40

What does PKA do in the liver?

Activates release of glucose from glycogen

Inhibit pyruvate kinase

Phosphorylates PFK2

41

No receptors for glucagon on

Muscle

42

When PFK2 kinase not phosphorylated, it

Catalyzes reaction fructose 6 phosphate into fructose 2,6 bisphosphate

43

When PFK2 is phosphorylated, it catalyzes reaction

Fructose 2,6 bisphosphate into fructose 6 phosphate

44

__ is a strong activator of PFK1

Fructose 2,6 bisphosphate

45

When glucagon present, there is ___ and ___ is inhibited

Less fructose 2,6 bisphosphate

PFK1