Exam 4 - Clinical treatment of antivirals Flashcards
(48 cards)
HSV 1 location
oral mucosa
HSV 2
genital mucosa
HSV 1+2
CNS
when should acyclovir be dose adjusted
renal and obesity
when should acyclovir be started in recurrent genital HSV
start with promodal or onset of symptoms
acyclovir
HSV encephalitis treatment
10mg/kg IV x14-21 days
valacyclovir
genital HSV
primary treatment
1g bid x7-10 days
valacyclovir
genital hsv
suppression treatment
500-1000mg qd in immuno
500mg bid in HIV
what is the major DDI with famiciclovir
probenicid
will decrease renal function and increase the serum concentration
what is varicella zoster virus
DNA virus that can cause chicken pox and later shingles
what is the preferred drug for shingles
valacyclovir
when should famciclovir be used in VZV
shingles only
start within 72 hours of onset
who is most likely to get CMV
children or those with weakened immune systems
how can resistance to ganciclovir occur
UL97 gene mutation leading to viral kinase deficiency
what are three counseling points for ganciclovir
take with food
renally dose adjust
avoid other cytotoxic drugs (probenecid)
what is the most important AE of ganciclovir
bone marrow suppression
is BM suppression reversible in ganciclovir
yes
monitor labs
what CMV treatments is ganciclovir used for
CMV retinitis
CMV esophagitis, colitis, pneumonitis, neurologic disease
prevention and treatment of CMV in transplant pts
what dose is used for ganciclovir in CMV patients
high dose
5/mg/kg IV q12 x14-21 days
valganciclovir dose adjustment
renally dose adjust
should valganciclovir be given with food
yes
when is valganciclovir used in CMV
CMV retinitis induction and maintenance
prevention of CMV in transplant patients
what is a monitoring parameter of letermovir
kidney function and DDIs
when is letermovir used
prophylaxis of CMV (rare)
