MCMP ID Drugs

Question 1

mechanism of b-lactams

Answer 1

resemble d-ala of peptidoglycans so transpeptidase bind to that instead of wall

Question 2

what in the structure causes b-lactams to be more suseptible to hydrolyis

Answer 2

less electronegative

Question 3

b-lactamase sensitive

Answer 3

penicillin G and V

Question 4

b-lactamase resistant parenteral

Answer 4

methicillin and nafcillin

Question 5

b-lactamase sensitive broad spectrum oral

Answer 5

ampicillin and amoxicillin

Question 6

b-lactamase resistant oral

Answer 6

oxacillin, cloxacillin, dicloxacillin

Question 7

b-lactamase broad spectrum parenteral penicillins

Answer 7

piperacillin

Question 8

b-lactamase inhibitor

Answer 8

clavulanic acid and sulbactam

Question 9

mechanism of cephalosporins

Answer 9

react w/ transpeptidase to inhibit peptidoglycan cross linking

Question 10

first gen cephalosporin

Answer 10

cefazolin and cephalexin
unreactive/methyl at C-3

Question 11

second gen cephalosporin

Answer 11

cefuroxime
carbamate

Question 12

third gen cephalosporin

Answer 12

ceftazidime
oxime ether/pyridinium ring

Question 13

fourth gen cephalosporin

Answer 13

cefepime
n-methypyrrolidine and methoximino

Question 14

carbapenem

Answer 14

imipenem
imine group

Question 15

Monobactams

Answer 15

aztreonam

Question 16

mechanism of vancomycin

Answer 16

binds to peptidyl side chain d-ala-d-ala to prevent cross linking
also inhibits transglycosylation

Question 17

lypoglycopeptides

Answer 17

oritavancin, telavancin, dalbavancin

Question 18

oritavancin half life

Answer 18

245h

Question 19

telavancin half life

Answer 19

9h

Question 20

dalbavancin

Answer 20

204h

Question 21

mechanism of synercid (dolfopristin + quinipristin)

Answer 21

dolfo - interferes w/ transpeptidyl transferase
quin - binds in ribosomal tunnel

Question 22

oxazolidone

Answer 22

linezolid

Question 23

linezolid mechanism

Answer 23

interacts w/ 50S ribosome unit

Question 24

aminoglycosides

Answer 24

tobramycin, amikacin, gentamicin, neomycin, paromomycin, streptomycin

Question 25

aminoglycosides mechanism

Answer 25

interferes w/ 30S ribosome

Question 26

macrolides

Answer 26

erythromycin, clarithromycin, azithromycin

Question 27

mechanism of macrolides

Answer 27

inhibit protein synthesis by binding reversibly to P site of ribosome and translocation of peptidyl-tRNA

Question 28

mechanism of clindamycin

Answer 28

binds to 50S ribosome

Question 29

severe side effects with clindamycin

Answer 29

pseudomembranous colitis and C. diff

Question 30

tetracyclines

Answer 30

minocycline, doxycycline

Question 31

tetracycline mechanism

Answer 31

binds to 30s of ribosome

Question 32

chloramphenicol mechanism

Answer 32

50s ribosome

Question 33

chloramphenicol toxicity

Answer 33

bone marrow suppression

Question 34

Quinolones

Answer 34

ciprofloxacin, levofloxacin, moxifloxacin

Question 35

quinolone mechanism

Answer 35

bind to cleavage complex and block replication fork and religation