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Flashcards in Exam 4 skin viral infections Deck (47):
1

Major viral causes of infections with skin presentation (vesicle or pestule)

HHV-1 (neuro, HRM), HHV-2, HHV-3, coxsackievirses A and B, Smallpox, Orf Virus

2

Major viral causes of infections with skin presentation (maculopapular rashes)

Measles, Rubella, Parvovirus B19, Roseolovirus (HHV-6 HHV-7), HHV-4, ECHO virus, West Nile virus

3

Major viral causes of infections with skin presentation (wart-like eruptions)

HPV, Molluscum contagiosum

4

What class is Herpes virus?

Baltimore class I

5

Does herpesvirus typically integrate into host genome?

no

6

How do herpesvirus stay in cells?

They make proteins that mediate genome persistence in host cells

7

What are conditions that can lead to reactivation of herpesvirus

Immune suppression, sexual contact, physical and emotional stress, severe temp changes, sunburns, hormonal changes, malnutrition, excessive fatigue

8

What are the alphaherpesviruses

HSV-1, HSV-2, varicella zoster virus

9

What are the betaherpesviruses?

Human cytomegalovirus (HCMV, HHV-6, HHV-7)

10

What are the gammaherpesviruses?

Epstein Barr virus, Kaposi sarcoma-associated herpesvirus

11

What are the 6 common childhood diseases?

1st: Measles, 2nd: strep pyogenes (scarlet fever), 3rd: rubella, 4th: SSSS (S. aureus), 5th: Parvovirus B19 (slapped cheeks), 6th: HHV6/7

12

What are the steps of a viral infection?

Attachment > penetration/adsoprtion > synthesis > assembly > release

13

How are HSV-1 and 2 transmitted?

Saliva, vaginal secretions, lesion fluid into eyes or breaks on the skin or mucose membranes

14

Who is at risk of HSV-1 and 2?

children (type 1), sexually active people (type 2). People in healthcare who come into contact with oral or genital secretions

15

What is the treatment for all herpesviruses?

Acyclovir

16

How is varicella zoster spread?

virus is transmitted by respiratory droplets or contact

17

Who is at risk of varicella zoster

Nearly everyone, immunocompromised people

18

Is there a vaccine for chickenpox?

Yes, live vaccine (Oka strain)

19

Where do herpesviruses usually stay latent?

Within neurons

20

What are the disease mechanisms for poxviruses (orthpoxvirus/smallpox)

Infection of respiratory tract, spreads through lymphatics and blood

21

What is the difference between smallpox and chickenpox in children?

Smallpox lesions all progress and mature at the same time, where chickenpox

22

How do you stop the spread of picornavirus?

Can use IgA

23

What causes hand, foot and mouth disease?

Coxsackie A virus (picornaviruses)

24

What is the useful way for remembering the maculopapular rashes?

"The odds plus 6"- Measles, Rubella, 5th disease (Parvovirus B19), Roseola (HHV6 and 7)

25

What are complications of measles?

otitis media, croup, bronchopneumonia, encephalitis, subacute sclerosing panencephalitis (SSPE)

26

What classification are Poxviruses (smallpox)?

Group 1, dsDNA

27

What classification are picornaviruses (coxsackie A)?

Group IV, ssRNA (+)

28

What group is measles virus?

Group V, ssRNA (-)

29

What group is rubella virus?

Group IV, ssRNA (+)

30

What are complications of a rubella virus?

Can infect fetus of a pregnant woman causing congenital defects

31

What is fifth disease also known as?

Erythema infectiosum, caused by parvovirus B19

32

What causes fifth disease?

parvovirus B19

33

What is the hallmark of fifth disease?

Slapped cheek appearance

34

What group is parvovirus B19 in?

ssDNA, group 2

35

What are complications of fifth disease?

aplastic crisis, acute polyarthritis, abortion

36

How can fifth disease cause an aplastic crisis?

infection of bone marrow erythroid precursor cells

37

What is sixth disease?

Roseola

38

What causes sixth disease (Roseola)?

HHV-6 and HHV-7

39

What are the hallmarks of sixth disease (Roseola)?

High fever (105F), that lasts for 3 days, on fourth day it disappears and maculopapular rash appears

40

What are the treatments for roseola?

No vaccine or treatments

41

What causes wart-like rashes?

Human papillomavirus, Molluscum contagiosum virus

42

How do you diagnose a either HPV or MCV?

clinical diagnosis, histology, microscopy, PCR

43

What group is HPV?

Group 1, dsDNA

44

What is a complication of HPV?

tumorigenic

45

What is the best screening procedure for cervical cancer?

Pap smear: will see huge infected cells

46

Can molluscum contagious cause cancer?

no

47

how do you prevent HPV spreading?

vaccine available, avoid direct contact, prevent cancer by screening cervix