Exam 5 lecture 29 and 30 Flashcards
(14 cards)
Ion channels
-Leak channels
-Gated channels (chemically gated, voltage gated, mechanically gated)
Depolarization
more positive
Hyperpolarization
More negative
Sodium action potential
-Big depolarization
Vm: -70 mV
Cl high outside
K high inside
Na high outside
Threshold
-Must have depolarizing stimulus to reach threshold
-More positive than Vm
-Voltage gated channels open
Voltage gated K channels
-Slower to open and close
-Open during repolarization phase
Voltage gated Na channels
-Has pore that allows it to be open
-Reset and capable of being opened
-Open during depolarization phase
Unmylinated
Continuous propagation
Slower
Mylinated
Nodes of ranvier are where voltage gated Na are.
AP jumps over myelin, faster
Synapse
-Short distance communication between a neuron and target cell
-Electrical signal is converted to chemical signal
Presynaptic: sender
Postsynaptic: reciever
Synaptic cleft: Gap between pre/post. Ensures one way communication
Reaches synapse
1.Triggers voltage gated Ca2+ channels
2. Ca2+ releases NT by making vesicles go to membrane and fuse
Ligand gated ion channels
-Open right when chemical binds
Common NT
Norepinephrine: ANS, sympathetic
Acetylcholine: Neuromuscular junction, parasympathetic
NT steps
- NT released by presynaptic cell
- Receptor type on postsyynaptic cell
[determines type of response] - Duration of NT and receptor interaction [determines strength of response]