24 yo female comes into ER. Vaginal spotting, history or PID, serum beta HCG increased and ultrasound shows suspicious mass in Fallopian tube. Where in the tube is this entity most likely located?
female children of women exposed to DES are at risk of cancer, what type of cancer?
Vaginal clear cell
Diagnosis from Vulvar biopsy lichen sclerosis heterotropism. Which is false?
Never seen in a woman under 30
Which statement is correct regarding mulluscum contagiosum?
You get a diagnosis from a vulvar biopsy: Bowens disease with mild dysplasia showing vin 1. What is wrong with this diagnosis?
High grade dysplasia process; severe dysplasia vin 3
Vulvar biopsy shows Paget's disease of the vulva. What's the immunohistochemical staining pattern?
CEA pos, cytokeratin pos, p63 neg, S100 neg
Vulgar biopsy: Malignment melanoma with superficial spreading, margins involved, breslows depth .67mm, negative for ulceration and lymphatic invasion. What immunohistochemical stains should be positive?
B and C (S100, melanin a(or MART-1))
Vaginal biopsy changes consistent with Gartners duct cyst. It's composed of cells from where?
composed of cells from the remnant Wolfian and mesonephric duct rests
Vaginal biopsy embryonal rhabdomyosarcoma. What is true?
A and D (also known as sarcoma botryoides and histologic feature include a Cambian layer)
Small cell carcinoma with neuroendocrine differentiation. Which of the following is not true?
CD 45 for LCA not positive Cytokeratin/81/83, synaptophysin, NSC (are all (+))
Cervical biopsy shows mild dysplasia: CIN I.
Low grade intraepithelial lesion
Which of the following is NOT a subtype of squamous cancer of the cervix?
Cervical biopsy endometrial adenocarcinoma grade 2/3 in the cervix. What is the staining pattern for endometrial cancer?
Vimetin pos, CEA neg, p16 neg, ERPR positive
Early secretory endometrium day 17 (postovulatory day 3) Which is the characteristic histologic feature?
Subnuclear vacuoles lined up
Endometrial biopsy: areas of stella phenomenon. What is the condition it is associate with?
Endometrial biopsy: Serous cancer of the endometrium. Which is the following is true?
Aggressive tumor associated with intraperitoneal spread
Endometrial biopsy: malignant mixed mesodermal tumor (MMMT) carcinosarcoma. Which of the following statements is true?
Like Dedifferentiated endometrial cancer and has a fulminant clinical course
Endometrial cancer staging summary. Which of the following statements is true for pt3b endometrial cancer?
Tumor extends into the vagina parametrial T3 is aggressive!!
Endometrial Stromal sarcoma. What is the stain?
Which of the following statements is true of polycyclic ovarian disease?
Also known as Stein-leventhal syndrome
Pathological report reads 27 yo female of dysfunctional uterine bleeding and endometrial hyperplasia without atypia. Which of the statements is true?
Low grade hyperplastic process initially treated hormonally with progesterin therapy
Path report of vaginal biopsy reads clear cell carcinoma grade 3 in a 24 yo female. Which of the following statements are correct?
Diethylstilbesterol (DES) exposure in the patients mother could be associated with this lesion
WHO staging summary for Serous cyst adenocarcinoma confined to the pelvis with positive pleural effusion. Which of the following is true?
Staging summary serous cyst adenocarcinoma. Which of the following is true?
Serous Borderline tumors with micro invasion have similar prognosis
Staging summary with mature teratoma prima ovari. What is wrong with the statement?
Not a mature teratoma
Endometrial Granulosis cell tumor of the adult type. What is true?
Estrogenic tumor effect
Sex cord stomal tumors with annular tubules.
Associated with peutz jaeger syndrome
Adenexal tumor of Wolfian duct origin. What is true?
Small cell cancer of hypercalcemic type. What is true?
All the above
Sertoli Leydig cell tumor. What is true?
Masculinizing/androgenizing cell tumor
Mucinous adenocarcinoma of the endometrium. What is true?
Low grade neoplasm
Endodermal sinus tumor. Which of the following is not true?
Is not a seminoma
Leydig cell tumor
Serous borderline tumors
Low malignant potential
Complete conjoined twins
Monochorionic and monoamniotic
Path report with diagnosis of complete hydatidiform mole. What's true?
Genotype 46 xx
Placental floor infarction
All of the above
Toxo, syphilis, TB, listeria, rubella, CMV, and HSV
Occurs in 1/10 pregnancies
All of the above
Uterine contents of gestational choriocarcinoma.
About 50% occur after molar disease
Changes associated in placental site trophoblastic tumor
Distinct membranous glomerulonephropathy
Complete adherence of decidua to muscle wall
Autopsy with cause of death as placental floor infarction
Misnomer, represents a fibrin deposition, not infarction
Acute chorioamnionitis and acute funisitis.
Ascending fetal infections, group b strep. and e.coli, associated with premature rupture of membranes, clinical signs are maternal fever All of the above?
Endometrial hyperplasia without atypia.
Low grade and low rate of progression
An endometrial biopsy expected to be day 23 but shows endometrial phase with glandular and stromal breakdown instead is indicative of what?
Anovulatory cycle DUB (dysfunctional uterine bleeding)
What is the endometrial carcinoma staging of a cancer that extends outside of the uterus but not into the true pelvis?
What is true of an adult granulosa cell tumor?
Cal Exner bodies and they’re associated w/ hyperestrogenism w/ feminizing effect
When the placenta implants over the cervix it is called:
HPV strains causing high risk of cancer
HPV 16 and 18
Something about meconium staining
sign of fetal stress
Ovarian tumors - if the capsule (of ovary) is intact it is stage?
Ovarian tumors - if you have a metastasis to capsule (of liver) it's stage
Ovarian tumors - if it metastasizes to liver parenchyma (through capsule) it's stage
Serous cystadenocarcinoma of low malignant potential borderline tumor
absence of destructive invasion
Symptoms in malignant surface epithelial tumors
abdominal pain, increased girth, peritoneal implants and ascites (in ovarian unit)
Ovarian surface tumors of borderline malignant potential
peritoneal implants but no destructive invasion, histologically malignant but not destructive invasion (low grade malignant)
Mesothelial lesions in the peritoneum