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Pharmacology II > Exam I- OEQ > Flashcards

Exam I- OEQ Flashcards

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1
Q

Which of the following antibiotics may NOT be used in pregnancy?

A

Doxycycline (Vibramycin)

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2
Q

Which of the following is MOST likely to have drug-drug interactions?

A

Fluconazole

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3
Q

Bevacizumab is commonly associated with which of the following side effects?

A

Increased bleeding

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4
Q

Which of the following prohibits the assembly of new retroviral cells?

A

Protease inhibitors

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5
Q

When is it appropriate for antibiotic prophylaxis?

A

Prosthetic heart valve

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6
Q

What procedure is considered high risk for infective endocarditis?

A

Tooth extractions

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7
Q

Which of the following viruses is not a life-long infection?

A

Influenza-A

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8
Q

Which of the following would lessen the effects of Influenza-A?

A

Oseltamivir (Tamiflu)

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9
Q

What is the MOA of fluconazole?

A

Prevents conversion of lanosterol to ergosterol

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10
Q

Which of the following scenarios suggests need for adjunctive systemtic antibiotics ina patient with periodontal abscess?

A

Systemic symptoms (fever, malaise, lympadenopathy)

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11
Q

What is the mechanism of action of Zoledronate (Zometa)?

A

Impairs ability of osetoclasts to form ruffled border to adhere to the bony surface

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12
Q

What is the mechanism of action of Zoledronic Acid (Zometa) on breast cancer?

A

Inhibits synergistic effect of osteoclasts on breast cancer

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13
Q

What is the mechanism of action of Bevacizumab?

A

Inhibits VEGF from binding VEGF receptor

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14
Q

To what class of drugs does Oxaliplatin belong to?

A

Platinum compounds

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15
Q

Which of the following antibiotics is commonly reccomended for prophylaxis CD4 count falls below 50 cells/mm3?

A

Azithromycin

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16
Q

In patient with xerostomia and mild oral candidiasis, which of the following is LEAST likely to cause irritation?

A

Nystatin suspension (Mycostatin)

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17
Q

Which of the following agents has the LOWEST potential for drug-drug interactions?

A

Nystatin suspension (Mycostatin)

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18
Q

You note a patient to be on once-weekly azithromycin. Which of the following comorbidities does the patient likely have?

A

HIV

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19
Q

Which of the following is used for HIV management?

A

Genvoya (Elvitegravir, Cobicistat, Tenofovir AF, Emtricitabine)

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20
Q

What is the mechanism of action for Nystatin?

A

Binds directly to ergosterol

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21
Q

Which of the following drugs have interactions with Warfarin?

A

Metronidazole (Flagyl)

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22
Q

Which type of bacteria is primarily seen in early odontogenic infections?

A

Gram positive aerobes

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23
Q

Which of the following is the main pathogen of bacterial endocarditis?

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A

Streptococcus

24
Q

Which of the following antibiotics is active against gram-negatives, anaerobes, and bacteriodes?

25
Which of the following antibiotics would be most appropriate for a dental infection lasting > 3 days?
Augmentin
26
What is the mechanism of action of beta-lactamases?
Binds to PCN binding proteins (PBP); inhibits cell wall synthesis
27
Which of the following antibiotics has the best activity against anaerobic organisms?
Metronidazole (Flagyl)
28
Which of the following cases would you NOT prescribe Cephalexin?
Blistering rash
29
Denosumab (Xgeva) has what mechanism of action?
Binks RANKL and prevents binding to RANK
30
A patient comes im saying they are receiving treatment for osteoporosis and also has active periodontal disease. Which of the following is true?
Risk for MRONJ is low (0-0.1%), so benefit of treatment outweigh risk, but should still be considered for prophylaxis
31
Which of the following has all of required information for a prescription?
Amoxicillin, 500mg x4 capsules x1 PO 30-60 minutes before appointment #4 capsule
32
Calculate the dose of amoxicilliun for a 37 lb kid using amoxicillin 20 kg/mg/day
125 mg/5 mL q8h
33
Which of these is a monoclonal antibody?
Denosumab (Xgeva)
34
A patient presents with new acute onset severe tooth pain. The patient relates that cold liquids are the primary irritants. Patient also relates that they have recently started treatment for cancer. Which of the following chemotherapy agents is most likely cause of tooth pain?
Oxaliplatin
35
All of the following are beta-lactams except?
Azithromycin
36
Streptococcus viridans has the greatest resistance to?
Azithromycin
37
Which of the following describes why we prescribe Amoxicillin 3x/day?
Its half life is 1-hour, and is concentration dependent
38
What bacteria is responsible for periodontal abscesses?
Bacteroides
39
Which of the following antibiotics has the highest association with causing C. Diff infection?
Clindamycin (Cleocin)
40
Which antibiotic most commonly has drug-drug interactions?
Erythromycin
41
What systemic antibiotics would you use for an already immunosuppressed patient?
Amoxicillin
42
What drug is known to cause immunosuppression?
Methotrexate
43
Clavulanate helps beta-lactams againt bacteria that produce ___?
Beta-lactamase
44
Diarrhea is a common side effect of which of the following?
Augmentin
45
Which of the following is not recommended in the recipe for Magin Mouthwash?
Decamethasone
46
Patient has something, when would you prescribe her Amoxicillin?
Blistering rash before Amoxicillin
47
Which of the following drugs have interactions with Warfarin?
Fluconazole
48
What can NOT cause MRONJ?
Tacrolimus
49
Which of the following is the backbone of HAART?
Nucleoside reverse transcriptase inhibitors
50
Which procedure is considered high risk for infection endocarditis?
Manipulation of gingiva
51
Which of the following drug classes can cause adverse lipid effects and increased fat distribution?
protease inhibitors
52
Which of the following drugs acts directly on cell wall synthesis?
Amoxicillin
53
A patient comes in and says he is on Cyclosporin, which of the following is NOT true?
He is at risk for MRONJ
54
Initiation of fluconazole for oralpharyngeal candidiasis would create a drug interaction with which of the following medications?
Cyclosporine
55

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