Exocrine pancreas Flashcards
(24 cards)
Fuzapladib antagonises what?
Leukocyte function associated antigen 1 antagonist ; prevents extravasation of neutrophils and formation of neutrophil extracellular traps
What proportion of dogs with pancreatitis have normal cholesterol and trigs? How do lipoprotein profiles differ in dogs with pancreatitis?
a) >70% (just 18% had hypertrophic, 24% increased cholesterol) b) Lipoprotein profiles differed significantly as dogs with pancreatitis had high LDL and lower HDL and triglyceride-rich lipoproteins than healthy controls
what canine pancreatic lipase assay is most reliable and repeatable?
Spec cPL
Which endogenous inhibitor of NO synthesis may be a useful biomarker for acute pancreatitis with an association with mortality? Which pancreatitis clinical scoring system does this biomarker correlate with?
Asymmetric dimethylarginine (ADMA) - correlated with Canine AP severity (CAPS); Dogs with CAPS ≥11 had higher serum ADMA concentrations than did dogs with CAPS <11
Are you more likely to obtain false positives or false negatives when running fPL ?
False negatives higher proprotion than false positives; positive spec fPL result indicates that pancreatiits is a probable dx but test cannot be used to rule dx out.
Reduced levels of which coagulation factor are associated with increased death in pancreatitis?
antithrombin (and also higher CAPS score in non survivors) (dogs with AP had lower antithrombin and higher CRP, IL6 and TNFa compared to controls)
elevated DGGR lipase in hospitalised dogs is associated with what effect on survival?
higher mortality (NB DGGR lipase elevated with variety of conditions in critically ill dogs - renal, endocrine, immune mediated, upper airways obstruction ..)
what percentage of dogs with acute pancreatitis associated EHBDO that survived had only medical management?
94% (NB also that tbil increase can lag behind improvement in clinical signs)
Which medication affects DGGR lipase in dogs and how?
prednisolone increases DGGR lipase (but not by a clinically significant degree - all results in paper remained below upper RI)
elevated amylase activity in feline bile may suggest what?
dilated cystic duct leads to pancreatic juice reflux secondary to dilatation.
which cut off value for DGGR lipase has high sens and spec for acute pancreatitis? What agreement is there between DGGR lipase and quantitative cPL?
DGGR lipase >42.15 (sens 81%, spec 92.1% for acute pancreatic) - agreement of DGGR lipase >42.15 and cpL - kappa of 0.8 if Cpl >200 and 0.75 if Cpl >400
which scoring systemi is positively correlated with cPLI, CRP and negatively correlated with survival to discharge in dogs with pancreatitis?
modified canine activity index
What proportion of cats with EPI have unremarkable pancreatic ultrasound?
39%
what impact does CKD have on fTLI concentrations?
fTLI significantly higher in CKD cats than healthy cats (fPLI not diff between CKD and healthy cats)
what factors increase likelihood of ultrasonographic diagnosis of pancreatitis?
increased lipase, previous episodes of pancreatitis and imager told ‘suspicion of pancreatitis’
Which miRNA is elevated in acute pancreatitis in dogs?
miRNA 375
how quickly would lipase be expected to normalise in treatment of canine acute pancreatitis?
2 days
elevations in which biomarker are associated with emergency revisits in dogs with chronic pancreatitis?
DGGR lipase
how do serum calcidiol, vitamin D receptor and vitamin D binding protein concentrations in dogs with acute pancreatitis compare to healthy control dogs?
dogs with acute pancreatitis have lower calciciol and lower vitamin d receptor expression than controls. Vitamin D receptor expression higher in survivors than non survivors and negatively correlated with cPL and CRP. No difference was observed in serum VDBP concentrations between the groups.
what impact does fluzapladib have on clinical variables?
modified clinical activity index (MCAI) score on Day 3 improved, no improvement in secondary variables (canine acute pancreatitis clinical severity index (CAPCSI) scores and serum concentrations of canine pancreatic lipase immunoreactivity, cytokines, and C-reactive protein.)
In dogs with normal pancreas, what proportion have abnormal cPLI?
7.5%
what diagnostic finding may persist beyond clinical and biochemical resolution of acute pancreatitis?
Ultrasonographic changes
Administration of prednisolone at anti-inflammatory doses to healthy cats had what effect on serum lipase and PLI concentration?
No significant increase in serum lipase or PLI
English cocker spaniels with chronic pancreatitis can show similarities to humans with IgG4-RD - what other organs/ clinical manifestations are common?
Higher frequency of KCS, proteinuria, anal gland disease, atopy, other immune mediated disease. Those with blue roan coat had a strong association with CP.
