exotoxins Flashcards Preview

DIT > exotoxins > Flashcards

Flashcards in exotoxins Deck (27):
1

G+ or G- produce exotoxins

Gram positives

2

inhibits ACh release, flaccid paralysis

botulinum

3

phospholipase that causes gas gangrene

clostridium alpha toxin

4

inhibits the inhibitor of adenylate cyclase -> whooping cough

pertussis toxin

5

stimulates adenylate cyclase -> chloride and water into gut, diarrhea

cholera and heat-labile ETEC

6

destroys leukocytes

s. aurues
hemolysis and panton-valentine leukoceidin

7

composed of edema factor, lethal factor, and protective antigen

anthracis

8

enterotoxin causing rice-water diarrhea

vibrio cholera, heat labile ETEC

9

causes scarlet fever

strep pyogenes

10

causes toxic shock syndrome

TSST-1 (s aureus)

11

inactivates EF-2 -> pseudomembranous pharyngitis

diptheria

12

inactivates EF-2 -> host cell death

exotoxin A from Pseudomonas

13

blocks the release of the inhibitory neurotransmitter glycine

tetanospasmin

14

corynebacterium diptheriae

diphtheria toxin (inactivates EF-2)

15

Pseudomonas

exotoxin A (inactivates EF-2 and causes cell death)

16

Shigella

shiga toxin (inactivates 60S ribosomes)
GI mucosal damage -> dysentery, HUS

17

Enterohemorrhagic E. coli (o157:H7)

shiga-like toxin (inactivates 60S ribosome)
HUS and bloody diarrhea

18

ETEC

Heat-labile (overactivates adenylate cyclase -> increases Cl secretion)
heat-stable (overactivates guanylate cyclase -> decrease NaCL resorption)
both cause watery diarrhea

19

bacillus anthracis

edema factor (mimics adenylate cyclase)
black eschar

20

vibrio cholerae

cholera toxin (overactivates adenylate cyclase by permanently activating Gs)

21

Bordatella pertussis

overactivates adenylate cyclase by disabling Gi
whooping cough

22

Clostridium tetani

tetanospasmin cleaves SNARE
prevents release of GABA and glycine

23

clostridium botulinum

botulinum toxins A-G cleave SNARE
flaccid paralysis prevents stimulatory ACh signals

24

clostridium perfringens

alpha toxin degrades tissue and cell membranes (phospholipase)
myenecrosis and hemolysis because of degradation of phospholipase C

25

streptococcus pyogenes

streptolysin O degrades cell membranes and lyses RBC
antibodies used to diagnose rheumatic fever

26

staphylococcus aureus

toxic shock syndrome toxin (TSST-1) acts as superantigen

27

streptococcus pyogenes

Exotoxin A acts as superantigen