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Flashcards in Micro Deck (266)
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1

ampicillin/amoxicillin coverage

G(+) and HELPSS
Haemophilus
E. coli
Listeria
Proteus
Salmonella
Shigella

2

organisms not covered by cephalosporins

LAME
Listeria
atypicals (chlamydia, mycoplasma)
MRSA
Enterococci

3

first gen cephalosporins

cefazolin, cephalexin
PEcK and G(+)
Proteus, E. coli, Klebsiella

4

second gen cephalosporins

cefoxitin, cefaclor, cefuroxime
HENS PEcK
Haemophilus
Enterobacter
Neisseria (not gonorrhea)
Serratia
Proteus, E. coli, Klebsiella

5

third gen cephalosporins

ceftriaxone (excreted in bile), cefotazime, ceftazidime
G(-) bad guys
meningitis and gonorrhea
ceftazidime for pseudomonas

6

fourth gen cephalosporins

cefepime
good pseudomonas and broad G(+)

7

toxicity of cephalosporins

increased nephrotoxicity with aminoglycosides
disulfiram like reaction

8

given prior to surgery to prevent s. aureus infections

cefazolin (1st gen)

9

side effects of vancomycin

red man syndrome (mast cell degranulation)
NOT: nephrotoxicity, ototoxicity, thrombophlebitis

10

resistance to vancomycin

change of D-ala-D-ala to D-ala-D-lac

11

protein synthesis inhibitors

Buy AT 30, CELL at 50
30s: aminoglycosides, tetracyclines
50s: chloramphenicol, clindamycin, erythromycin (macrolides), linezolid

12

use for tetracyclines

VACUUM THe BedRoom
vibrio cholera
acne
chlamydia
ureaplasma urealyticum
mycoplasma pneumoniae
tularemia
H. pylori
Borrelia burgdorferi
Rickettsia

13

photosensitivity

SAT:
sulfonamides, amiodarone, tetracyclines

14

what to avoid with tetracyclines

milk, antacids, iron because they inhibit the absorption of tetracyclines

15

given for bowel surgery

neomycin

16

toxicity of aminoglycosides

nephrotoxicity, ototoxicity, teratogenic

17

clinical uses for macrolides

PUS
Pneumonia: mycoplasma, chlamydia, legionella
URI: strep pneumoniae, strep pyogenes
STD: chlamydia, gonorrhea

18

resistance to macrolides

mehtylation of 23S RNA subunit of 50S

19

clinical use for chloramphenicol and toxicity

use: meningitis (H. flu, N men, strep pneum)
tox: gray baby syndrome, aplastic anemia

20

clinical use of clindamycin and toxicity

use: MRSA abscess
tox: C. difficile

21

streptogramins

quinupristin and dalfopristin
bind 23s subunit of 50s
use: MRSA, VRE, staph and strep skin infections
SE: hepatotoxicity, pseudomembranous colitis, inhibits cP450 system

22

what causes:
gray baby
gray man
red man

baby: chloramphenicol
man: amiodarone
red man: vancomycin

23

prophylaxis for meningococcal infection

coprofloxacin
rifampin for children

24

prophylaxis for gonorrhea

ceftriaxone

25

prophylaxis for syphilis

benzathine penicillin G

26

prophylaxis for history of recurrent UTI

TMP-SMX, nitrofurantoin, amoxicillin

27

prophylaxis for pneumocystic jiroveci

TMP-SMX if CD4<200, dapsone if sulfa allergic

28

prophylaxis for endocarditis (surgery or dental procedure)

penicillins, aminopenicillins, cephalexin

29

prophylaxis for pregnant women with Group B strep

ampicillin during pregnancy

30

prophylaxis for strep pharyngitis in child with prior rheumatic fever

oral penicillin