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Flashcards in immunology Deck (20):
1

molecules expressed on antigen presenting dendritic cells

MHC 1 and II
B7
CD40

2

EM of a dendritic cell with Langerhans cell histiocytosis

Birbeck granule (tennis racket cells)

3

surface markers on B cells

CD19, 20, 21
CD 40
CDB7
IgM, IgD

4

What initiates V(D)J recombination

RAG-1 or RAG-2 that recognize recombination signal sequences (RSS)

5

what viral vaccines may be dangerous to egg allergy

influenze and yellow fever

6

precursor of 6-mercaptopurine

azathioprine

7

Ab that binds to CD3 on t cells

muromonab

8

Ab that binds IL-2 receptor on activated T cells

daclizumab

9

inhibits inosine monophophate (IMP) dehydrogenase

mycophenolate mofetil

10

inhibits calcineurin resulting in the loss of IL-2 and blocks T cell differentiation and activation

cyclosporine

11

binds FK-binding protein (FKBP) leading to loss of IL-2 production

tacrolimus

12

binds FKBP12 leading to inhibiton of mTOR and T cell proliferation

sirolimus

13

used for lupus nephritis

azathioprine
mycophenolate and cyclosporine off label

14

metabolized by xanthine oxidase, therefore allopurinol increases the toxicity

azathioprine

15

X-linked immunodeficiencies

WACH
wiskott-aldrich
Bruton Agammaglobulinemia
+/- chronic granulomatous disease
+/- hyper IgM syndrome

16

wiskott-aldrich syndrome

WAITER
Wiskott
aldrich
immunodeficiency
thrombocytopenia and purpura
eczema
recurrent pyogenic infections
increased IgA, decreased IgM

17

chronic granulomatous disease cause and susceptible organisms

no NADPH oxidase
catalase + organisms:
S. aureus, E. coli, Aspargillus, Klebsiella, Candida

18

young pt with tetany from hypocalcemia, and candidiasis resulting from immunosuppression

thymic aplasia-> T cell deficiency

19

eczema, recurrent cold abscesses, high serum IgE

hyperimmunoglobulin E (Job disease)

20

large lysosomal vesicles in phagocytes

Chediak-Higashi
defective LYST (lysosomal transport) gene