1
Q
What are dendrites initially like in the dendrites? What does attenuation in the dendrites do to EPSP waveform and amplitude?
A
Large (high resistance) and fast (low capac.)
Broader waveform (longer duration), less amplitude
2
Q
What is the beta subunit in Na+ ion channels
A
- Tightly bound to and much smaller than alpha subunit
- 4 different types of beta subunits
3
Q
Describe metabotropic actions of GABAergic signaling
A
- GABA_B receptors are coupled to G-proteins, specifically the Gi/o type, which inhibits adenylyl cyclase activity.
- This coupling results in a reduction of cyclic AMP (cAMP) levels.
PRESYN: Inactivation of Ca2+ channels
POSTSYN: GIRK K+ outflow - Slower and longer lasting effects than GABA_A
- influence long-term synaptic changes by modulating neurotransmitter release and interacting with other signaling pathways
