Extracellular matrix

Question 1

Outside the cell is an extensive 3D network of

Answer 1

Macromolecules

Question 2

The most significant enzymes in the Extracellular matrix

Answer 2

Matrix metalloproteinases. These are extracellular remodeling enzymes and help the highly dynamic structural network undergo continuous remodeling.

Question 3

The 2 main classes of macromolecules outside of the cell

Answer 3

1. Fibrous proteins.

2. Glycosaminoglycans (GAGs)

Question 4

The two main categories of fibrous proteins and examples

Answer 4

1. Structural (collage and elastin)

2. Adhesive (fibronectin and laminin)

Question 5

Most GAGs are linked to a specific core protein, forming ____

Answer 5

proteoglycans (another example of GAGs)

Question 6

What do GAGs form in the extracellular matrix? and how does it get to the extracellular matrix?

Answer 6

Hydrated gel is synthesized intracellular and secreted outside the cell via exocytosis.

Question 7

Functions of the matrix

Answer 7

• provide cells with structural support
• anchor cells in place
• bind cells together, forming tissues
• regulates a number of cellular functions (adhesion, growth, migration, and differentiation)