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Flashcards in Fatty Acid Biosynthesis Deck (11)
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1

What types of cells does FA-synthesis occur?

Liver cells and adipose cells

2

Where in the cell does FA synthesis occur?

Cytoplasm

3

What is the initial pre-cursor for FA synthesis

Acetyl CoA (shuttled from matrix to cytoplasm by combining with OAA to form citrate).

4

Malonyl-CoA

Formed via Acetyl-CoA carbolase and ATP.

Primary building block in FA biosynthesis

Presence Blocks FA-oxidation by antagonizing the carnations shuttle pathway

5

ATP-citrate lyase

Cleaves acetyl-CoA from citrate (its carrier molecule from the matrix to the cytoplasm)

Malate is also formed and gets regenerated into pyruvate for CTC

6

3 fatty acrylic-CoA can form what?

Triglycerides

7

Triglycerides and FA synthesis occurs under what conditions?

Hyperglycemia (to much free glucose and Acetyl CoA)

8

Lipoprotein

Carrier molecules of triglycerides. Allows triglycerides to move from liver cells to blood stream and ultimately to adipose tissues if not used.

-VLDL- transfers fatty acids to adipose cells in the presence of excess acetyl-CoA

9

3 key products in acetyl-CoA indirect shuttle

Citrate (6C)
OAA (4C)
Pyruvate (4C)

10

Rate-limiting step of FA-synthesis?

Ace-CoA carboxylase forming Malonyl-CoA

-inhibited by glycogen
-activated by insulin

11

Fatty Acid Synthase (FAS)

Main catalysis of FA-synthesis

Uses NADPH to take 2 C from malonyl-CoA to help form a fatty acid

- almost always produces palmityl-CoA