Flashcards in Fatty Acid Biosynthesis Deck (11)
What types of cells does FA-synthesis occur?
Liver cells and adipose cells
Where in the cell does FA synthesis occur?
What is the initial pre-cursor for FA synthesis
Acetyl CoA (shuttled from matrix to cytoplasm by combining with OAA to form citrate).
Formed via Acetyl-CoA carbolase and ATP.
Primary building block in FA biosynthesis
Presence Blocks FA-oxidation by antagonizing the carnations shuttle pathway
Cleaves acetyl-CoA from citrate (its carrier molecule from the matrix to the cytoplasm)
Malate is also formed and gets regenerated into pyruvate for CTC
3 fatty acrylic-CoA can form what?
Triglycerides and FA synthesis occurs under what conditions?
Hyperglycemia (to much free glucose and Acetyl CoA)
Carrier molecules of triglycerides. Allows triglycerides to move from liver cells to blood stream and ultimately to adipose tissues if not used.
-VLDL- transfers fatty acids to adipose cells in the presence of excess acetyl-CoA
3 key products in acetyl-CoA indirect shuttle
Rate-limiting step of FA-synthesis?
Ace-CoA carboxylase forming Malonyl-CoA
-inhibited by glycogen
-activated by insulin