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Flashcards in Gluconeogenesis Deck (7)
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1

What cells undergo gluconeogenesis?

Liver and kidney cells only

Primarily liver cells though

2

What precursors does gluconeogenesis use?

Noncarbohydrate precursors (mainly amino acids)

3

Irreversible reactions/enzymes of gluconeogenesis

-Glucose 6-phosphatase *1st step*

(G6-P -> Glucose)

-Fructose 1,6 biphosphatase *2nd step*

F1,6-BP -> F6-P

- Pyruvate carboxylase *3rd step*

Pyruvate - > OAA

- PEP carboxykinase *3rd step*

OAA -> PEP



4

Why are there 4 irreversible reactions in gluconeogenesis, but only 3 irreversible reactions in glycolysis?

Pyruvate -> PEP requires two enzymes since PEP is very high energy molecule

5

Net products of gluconeogenesis

1 Glucose

2 NAD+

6

Net reactants of Gluconeogenesis

2 pyruvate

2 NADH
4 ATP and 2 GTP (used in conversion of pyruvate to PEP)

7

What intermediate moves in Gluconeogenesis?

OAA moves from matrix to cytoplasm indirectly