Flashcards in Fatty Acid Oxidation Deck (12)
Loading flashcards...
1
Where does fatty acid oxidation occur?
Mitochondrial matrix
2
Net products of Fatty Acid Oxidation
Acetyl-CoA
NADH
FADH2
Removes 2 carbon fragments from the carboxyl end of a fatty acyl CoA
3
Acyl-CoA Dehydra
Enzyme that catalyses the first step of FA oxidation
- dehydrogenation of two carbon atoms to form FADH2
- generates a trans double bond between C2-C3
4
delta-Enoyl-CoA hydratase
Enzyme that catalyses the 2nd step of FA oxidation
- uses water to add a hydroxyl group to the C3 of the trans double bond
- forms hydroxyl FA
5
3-HA-CoA dehydra
Enzyme that catalyses the 3rd step of FA oxidation
- removes 2 hydrogens to form NADH and Keto FA
6
3-KA-CoA Thiolase
Enzyme that catalyzes the 4th step of FA oxidation
- removes acetyl CoA group from fatty acid
- spontaneously adds a free CoA group
- net result is a 2 carbon less fatty acid CoA
7
Palmitic acid produces how many acetyl CoA
8
(And 7 NADH/FADH2)
8
How is FA oxidation stopped?
No oxygen present
- requires ETC and CTC to be working
9
Pre-step in FA oxidation
Acrylic-CoA synthase binds a CoA SH via thioester linkageto a fatty acid via ATP in the cytoplasm of the mitochondria
10
Carnations shuttle
Shuttles CoA-SH fatty acid from cytoplasm to the matrix to undergo FA oxidation
- rate limiting step of FA oxidation
11
Why is energy stored as fat over carbs/protein
Fat gives a higher energy yield per unit weight as long as aerobic respiration is occurring
Fats also have higher calorie count (9 per g)
12
