Female Reproductive diseases Flashcards Preview

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Flashcards in Female Reproductive diseases Deck (27):
1

The exocervix and endocervix are covered with what tissues?

The exocervix is covered with stratified squamous epithelium and the endocervix is covered with columnar epithelium

2

The columnar epithelium is responsible for?

Cervical mucous secretion

3

Describe the nucleus of cells in the exocervix.

Small nuclei with a lot of cytoplasm

4

What is the transformation zone?

The area between the original SC junction and the current one, this is where cancers occur

5

How is the SC junction viewed?

Colposcopy

6

What causes polyps?

Trauma, spotting or post-coital bleeding

7

Post-coital bleeding is a red flag for?

Cervical cancer

8

Who gets cervicitis? What conditions make it worse?

Any woman that has had sex. STDS make it worse

9

Presence of pus (mucopurulent cervicitis_ in the cervix usually indicates?

Gonorrhea or chlamydia

10

HPV 6 and 1 1 cause?

Condyloma, low risk, warts

11

HPV 16 and 18 cause?

Cervical disease, high risk

12

What are 3 problems caused by gonorrhea and chlamydia?

1. Ectopic pregnancy
2. Pelvic inflammatory disease
3. Infertility

13

What is trichomonad vaginalis?

A protozoa that causes strawberry cervix

14

When HPV is found in cancers it is often?

Integrated into the host DNA

15

The ability of HPV to act as a carcinogen depends on? Why?

Viral proteins E6 and E7, these interfere with activity of tumor suppressor proteins

16

The contagious form of HPV that produces warts presents as?

Episomal or nonintegrated

17

Histologically HPV is marked by the presence of?

Koilocytes and raisinoid nuclei

18

What is a marker for dysplasia? Marker of high risk HPV?

Ki67 and p16 respectively

19

Which 2 forms of HPV account for most cervical cancers?

16 and 18

20

Infections last longer with low or high risk HPV?

High

21

What happens to most cases of low risk?

Revert to normal

22

What happens to most cases of high risk?

They persist

23

Is the pap smear a good diagnostic test?

No

24

High grade dysplasia appears how histologically?

Large nuclei with mouse bite irregularities. The nuclei are dark due to large amounts of chromatin

25

Most cervical caners are?

Squamous cell carcinoma

26

What cells are used for research that were made from cervical cancer?

HeLa cells

27

What measurements are used to determine staging?

Depth and width