Final 3 Flashcards
When manufacturing a sterile dosage form, which of the following tests of typical liquid drug products must be performed on 100% of vials manufactured?
a. sterility
b. appearance
c. endotoxin
d. All of the above
b. appearance
True/False: Suppositories are the only dosage form available for rectal and vaginal delivery
False
A pulmonary drug product MUST be sterile if:
a. a solid
b. all drugs administered via the pulmonary route must be sterile
c. a liquid
c. a liquid
What aspect of otic formulations is usually the most important for its effectiveness?
a. packaging
b. pH
c. viscosity
d. tonicity
c. viscosity
TRUE/FALSE: Topical formulations are among the most complex dosage forms
False
Which of the following statements is true?
a. local delivery uses chemical targeting strategies to maximize concentration of drug at desired site of action
b. systemic delivery means drug is delivered to the whole body by means of drug system, can only be achieved via injection
c. Most routes of administration can be used for either local or systemic delivery
d. none of these
c. Most routes of administration can be used for either local or systemic delivery
The easiest APIs to formulate are:
a. Class I
b. Class IV
c. Class II
d. Class III
a. Class I
The types of drugs that are most easily delivered systemically via the nasal route are:
a. hydrophobic
b. hydrophilic
c. both
d. systemic delivery via the nasal route isn’t possible for any drugs
b. hydrophilic
The major environmental factors which lead to a drug’s instability are:
a. pH and particle size
b. water and oxygen
c. light and heat
d. b and c
d. b and c
If you have a lipophilic drug and would like to design a suppository with a slow-release rate, the base you choose should be:
a. a PEG base
b. a hydrogenated vegetable oil base
c. neither, because both would yield a rapid release rate
d. either, because both would yield a slow-release rate
b. a hydrogenated vegetable oil base
To be pharmaceutically equivalent two products must have all but the same:
a. route of administration
b. strength
c. dosage form
d. packaging
d. packaging
The purpose of adding excipients into a dosage form is:
a. to make the drug product acceptable to the patient
b. for marketing and identification
c. to make manufacturing easier
d. it can be any of these
c. to make manufacturing easier
What is the most common disease of the middle ear?
a. Meniere’s D
b. Swimmer’s Ear
c. Otitis externa
d. otitis media
d. otitis media
When a PLGA matrix containing drug is injected into a patient, three phases of drug release are observed. An initial fast release is followed by a period of constant release, and then finally a quick release rate is observed. Which of these three phases represents the desired drug release rate?
a. the initial burst
b. the final release of the remaining drug
c. the middle phase of constant release
d. all three are part of the desired release profile
c. the middle phase of constant release
If you were filling capsules, which of the following materials would be most desirable in terms of its physical characteristics?
a. granulated sugar
b. baking flour
c. powdered sugar
d. all are equal
a. granulated sugar
