Flashcards in Foreign Body Response and Encapsulation Deck (9)
When does the foreign body response occur?
When materials of non degradable, synthetic, and metallic components are implanted for long-term use
How is the foreign body response perceived at the clinical level?
Expected to occur
associated with negative implications for implant longevity
Does the foreign body response occur for biodegradable materials?
Only when it has not be designed appropriately
Describe the cascade of the foreign body response.
1: Blood-material interaction
2: proteins adsorb and create a film-like deposition
3: cell infiltration of platelets and monocytes
4: the adhered cells release cytokines and chemokine for inflammation response
5: cells are recruited for tissue repair
6: fibrous encapsulation of tissue
What is M1 macrophage?
pancake, flat structure
What is the M2 macrophage
wound up structure
What is (post) chronic inflammation?
activated when macrophages remain at the implant site
lasts weeks to months
causes granulation tissue formation by depositing ECM with robust angiogenesis at implantation site
If non-degradable, foreign body response begins
What is the "foreign body giant cell"?
The fusion of several macrophages to try to eat the massive materials chunk