Flashcards in Forensic Toxicology Deck (22):
What is Toxicology
study of adverse effects of chemicals on living organisms, organ systems, individual organs, tissue and cells.
study of symptoms, mechanisms, treatments and detection of poisoning.
what are the toxic compound groups
- Volatile organic compounds
- Pesticides and persistent organic pollutants
who was the founder of toxicology?
Paracelsus was the founder of toxicology.
Why is dose important?
Sensitive and selective methods are necessary to establish toxic doses
Dose (e.g. mg/kg body weight)
defines as the amount of a substance added at a certain time. perceive as the total amount of a poison administered.
dose rate (e.g. mg/kg body weight a day)
Amount of a substance administered to an organism during a defined time span
does in soil water air food
dose or dose rate
amount in body e.g in blood
dose in tissue
dose at tissue level e.g liver
biologically effective dose
concentration of compound at target molecule
what are the applied toxicology
- Forensic toxicology
- Occupation – risk at work
- Clinical- toxic induced diseases
- Developmental- induced malformations in embryos or foetuses
identify and describe the toxicological profilings (carcinogenic, mutagenic, neurotoxic)
identify and describe how the toxic compounds exert their toxic effects
risk assessment and risk management, determination of risk based on descriptive and mechanistic toxicology to develop safety regulations
what is forensic toxicology
detection and measurement of xenobiotics in biological or other specimens
- when toxicological and analytical chemical techniques and methods are applied in legal context
main purpose- to verify a crime could be behind an acute/chronic poisoning
(murder by poison, illegal drugs at workplace, doping, alcohol, chemical spills)
- when toxicological and analytical chemical techniques and methods are applied to identify compound responsible for an acute/chronic poisoning
main purpose to keep a poisoned person alive
(suicide, attempted suicide, unintended poisoning, accidental acute/chronic poisoning)
- results from an accident, error, carelessness or an unexpected situation in the working environment
- house accidents
- due to medical or paramedical treatment ( e.g. contaminant)
self medication or experimentation
intoxicate on purpose