Form 6 Flashcards
(32 cards)
Alcoholic hepatitis labs
ASTx2 > ALT
↑ GGT
↑ Ferretin
Ferritin
acute phase reactant
binds/ sequesters iron to inhibit microbial iron scavenging
Rx for social anxiety
SSRI
BB for “performance” anxiety
Family members of pertussis pt
recieve macrolides
Neonatal polycythemia s/s
HCT > 65%
resp distress
hypoglycemia
neuro
What is wrong in Bruton
no B cells
Recurrent bacterial infections
↓ Ig of all classes
Selective IgA
deficiency
Most common 1°
immunodeficiency
↓ IgA with normal IgG, IgM levels.
Asymptomatic.
Can see Airway and GI infections, Autoimmune
disease, Anaphylaxis to IgA-containing products.
Common variable
immunodeficiency
Defect in B-cell differentiation
↓ plasma cells
↓ immunoglobulins
hyper-IgE syndrome
Job syndrome
impaired
recruitment of neutrophils to
sites of infection
↑ IgE, ↓ IFN-γ.
Hyper-IgM syndrome
defective CD40L on Th cells ↓ class switching X-linked
Severe pyogenic infections
early in life; opportunistic
infection with Pneumocystis,
Cryptosporidium, CMV.
Normal or ↑ IgM.
↓↓↓ IgG, IgA, IgE.
Wiskott-Aldrich
syndrome
T cells cant reorganize actin cytoskeleton
WATER: Wiskott-Aldrich: Thrombocytopenia, Eczema, Recurrent infections
↑ IgE, IgA.
↓ / normal IgG, IgM.
Chédiak-Higashi
syndrome
Microtubule dysfunction in
phagosome-lysosome fusion
Recurrent infections by staph and strept,
albinism, peripheral
neuropathy, neurodegeneration, infiltrative lymphohistiocytosis.
Chronic
granulomatous
disease
Defect of NADPH oxidase–> ↓ reactive oxygen
and ↓ respiratory burst
in pmns
↑ susceptibility to Catalase
⊕ organisms
Abnormal dihydrorhodamine and Nitroblue tetrazolium tests
Catalase
⊕ organisms
Nocardia Pseudomonas Listeria Aspergillus Candida E coli Staph Serratia, H pylori
Encapsulated ⊕ organisms
- Pseudomonas
- Strept pneumo
- Hib
- N meningitidis
- E coli
- Salmonella
- Klebsiella
- group B Strep
Leukocyte adhesion
deficiency
↑ neutrophils.
Absence of neutrophils at
infection sites
Recurrent bacterial skin and
mucosal infections, absent pus formation
DDX of pseudogout, also screen for?
hemochromatosis
Arrest of second stage of labor
no fetal decent after:
2 hours in G+
3 hours in nullipari
Dermatitis herpetiformis
deposits of IgA in skin
asc w/ celiac
rx: dapsone
Dapsone
similar to sulfomamides (SMX)
used in leprosey, profylaxisis to PCP, and dermatitis herpetiformis
s/e: G6PD hemolysis
Continuous machine-like murmur. Loudest at S2.
Patent ductus arteriosus
may have: Recurrent URI, “to-and-fro murmur” loud S2, bounding peripheral pulses, widened pulse pressure
a to and fro murmur means?
continuous
Tetralogy of Fallot parts
1- Pulmonary stenosis
2- RVH
3- Overriding aorta
4- VSD
Squatting: ↑ SVR, ↓ R -> L shunt, improves cyanosis.
rx: early surgical correction.
Hyaline casts
Nonspecific, can be a normal finding, often seen in concentrated urine samples
