Heme Onc

Question 1

hereditary spherocytosis in new born

Answer 1

macrocytic

jaundice, splenomegally, spherocytes

ddx w/ RBC fragility test w/ glycerol lysis

Question 2

Rx for child with ITP

Answer 2

No active bleeding= observation- most resolve 6 mo w/ no rx

bleeding: IVIG/ steroidsw

Question 3

Hereditary angioedema s/s

Answer 3

C1 esterase deficiency

edema everywhere
ab pain from intestine edema
NO urticaria

Question 4

Leukemoid rxn

Answer 4

WBC > 50,000 IN RESPONSE TO SEVERE INFECTION

HIGH ALK PHOS (vs CML will not have this)

Question 5

major toxicity of mycophenolate

Answer 5

immunosupressent

bone marrow supression

Question 6

examples of type 4 hypersensativity

Answer 6

tb skin test

allergic contact dermatitis

Question 7

aquied angioedema

Answer 7

low C1q

Question 8

SCID

Answer 8

absent t cells
dysfxn b cells
rx: stem cell transplant

Question 9

CVID vs bruton

Answer 9

CVID presents later in life and is less severe

Question 10

major toxcity of azathioprine

Answer 10

immunosupressant

diarrhea
leukopenia
hepatotoxic

Question 11

etidronate is?

Answer 11

bisphosphonate

Question 12

can you trust the g6pd assay

Answer 12

not really

Question 13

CGD defect

Answer 13

NADPH oxidase

cant kill cat + bugs

Question 14

most common side effect of cyclosporin

Answer 14

nephrotoxicity

Question 15

DIC labs

Answer 15

• thrombocytopenia
• prolonged PT and aPTT
• low fibrinogen
• schistocytes

Question 16

s/s of thrombotic throbocytopenic purpura

Answer 16

thrombocytopenia
hemolytic anemia
fever
neuro (ams)

Question 17

Pyruvate kinase deficiency

Answer 17

chronic hemolysis
big liver/spleen
skin ulcers
pigmented galstones

Question 18

Cancers most likely to raise AFP

Answer 18

testicular

liver

Question 19

What causes elevation of homocystine

Answer 19

folate or b12 deficiency

Question 20

Haptoglobin is decreased in?

Answer 20

hemoytic anemia

Question 21

Most common cause of isolasted thrombocytopenia

Answer 21

ITP

IgG vs plt membrane

ddx of exclusion

must check for hep c and hiv

Question 22

Hypochromic microcytic anemia

elevated iron

decreased TIBC

Answer 22

sideroblastic anemia

Question 23

coombs test detects?

Answer 23

autoimmune hemolytic anemia

Question 24

ddx of malaria

Answer 24

giemsa stain of blood

Question 25

Auer rods are seen in?

Answer 25

AML

Question 26

Leukocyte adhesion deficiency

Answer 26

impaired PMN migration deleyed umblical cord seperation

Question 27

chediak higashi

Answer 27

AR albino recurrent skin infections

Question 28

Post splenectomy rx

Answer 28

daily pcn x 5 years vaccines: anti-pneumococcal, haemophilus, meningococcal (best weeks BEFORE surgery)

Question 29

deleyed umblical cord seperation

Answer 29

leukocyte adhesion deficiency

Question 30

most common bleeding problem

Answer 30

von wilebrand prolonged bleeding and aPTT

Question 31

ABO mismatch rxn in blood transfusion

Answer 31

1 HOUR* fever, chills, flank pain, hemoglobinuria

Question 32

TRALI

Answer 32

6 HOURS* pulm edema

Question 33

Most common reaction to blood transfusion

Answer 33

febrile nonhemolytic rxn 1-6 hours fever, chills, mailase