Fructose Metabolism

Question 1

Initial step of fructose metabolism enzymes speicific for peripheral tissues and liver

Answer 1

Hexokinase
Fructokinase

Glut 5

Question 2

In non-hepatic tissues, fructose is converted to… by hexokinase

Answer 2

Fructose 6 phosphate
And then to DHAP and GAP

Also, hexokinase has high Km for glucose

Question 3

Difference between Aldolase A and Aldolase B

Answer 3

Aldolase A in glycolysis pathway, converting fructose 1,6 bisphosphate to GAP and DHAP. Aldolase B converts DHAP and Glyceraldehyde

Question 4

Aldolase B defificiecy leads to

Answer 4

Accumulation of Fructose 1 phosphate

Leads to hypoglycaemia due to inhibition of gluconeogenesis