Gabapentin and pregabalin

Question 1

Indications

Answer 1

1. Focal epilepsies, usually as an add-on to other drugs
2. Neuropathic pain
3. Gabapentin- migraine prophylaxis
4. Pregabalin- generalised anxiety disorder

Question 2

Mechanism

Answer 2

Binds to voltage dependent calcium channels, preventing influx and therefore reduces neuronal excitability

Question 3

Important adverse effects

Answer 3

Drowsiness, dizziness and ataxia

Question 4

Important interactions

Answer 4

Use with benzos increases sedative effects

Question 5

How should gabapentin/pregabalin be prescribed?

Answer 5

Oral administration, starting with low dose

Question 6

How might gabapentin interfere with the results of a urine dipstick?

Answer 6

May cause a false +ve protein