Gastric cancers Flashcards
what are 95% of stomach cancers
adenocarcinomas
risk factors adeno
diet, H pylori, chronic gastritis with atrophy and incomplete intestinal metaplasia, microsatellite instability
what is the sequence of events in gastric adenocarcinoma
normal mucosa- super gastritis- atrophic gastritis- intestinal metaplasia- dysplasia- carcinoma
how much is HER2 expressed in adenocarcinoma- better or worse prognosis
in 20%. worse prognosis. blocked by trastuzumab (Herceptin)
what are the types of gastric cancer
macroscopic, localised, polypoid, ulcerating, stricturing
signs
weight loss, anaemia, pyloric obstruction, haematemesis, dyspepsia, mets
where are the main metastases
liver, ovaries, cervical lymph nodes
what are gastrointestinal stromal tumours
in the wall of the GIT, commonest in the stomach. may ulcerate, bleeding, obstruction
what lymphoma can be present in the stomach
B cell MALToma
