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GI Drug Facts Flashcards

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1
Q

Clinical term for heartburn

A

gastroesophageal reflux disease

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2
Q

What helps the tablet pass through the stomach?

A

Enteric-coating

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3
Q

What is acid-labile?

A

compound that is destroyed by acid

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4
Q

dosage form of Prilosec (Rx)

A

delayed-release capsule

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5
Q

dosage form of omeprazole (Rx)

A

delayed-release capsule

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6
Q

dosage form of Prilosec (OTC)

A

delayed-release tablet

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7
Q

dosage form of omeprazole (OTC)

A

delayed-release tablet

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8
Q

Strengths Prilosec (Rx)

A

10mg,20mg,40mg

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9
Q

Strengths of omeprazole (Rx)

A

10mg, 20mg, 40mg

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10
Q

Indications for PPI’s

A

GERD
erosive esophagitis
gastric ulcers
Zollinger-Ellison Syndrome

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11
Q

What is Zollinger-Ellison Syndrome?

A

A hypersecretory condition where too much gastric acid is produced

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12
Q

Dosing interval for PPI’s

A

Take 1 daily, 30 minutes prior to breakfast. Do not take with food-decreases absorption

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13
Q

Strength of Prilosec (OTC)

A

20mg

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14
Q

Strength of omeprazole (OTC)

A

20mg

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15
Q

Is Prilosec enteric-coated?

A

yes

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16
Q

What is contained in Zegerid?

A

NaHCO3 and omeprazole

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17
Q

Is Zegerid enteric-coated?

A

No

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18
Q

Strength of Zegerid-OTC

A

20mg ompeprazole

1100mg NaHCO3

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19
Q

Strength of Zegerid (Rx)

A

40mg omeprazole

1100mg NaHCO3

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20
Q

What does the NaHCO3 do?

A

neutralizes the gastric acid, providing instant heartburn relief and protecting teh omeprazole of acid degradation

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21
Q

Strength of Zegerid powder for oral suspension (Rx)

A

20mg omeprazole
1680mg NaHCO3

40mg omeprazole
1680mg NaHCO3

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22
Q

What is the mixture of esomeprazole?

A

S isomer of omeprazole

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23
Q

Composition of Nexium

A

gel capsule containing enteric coated granules

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24
Q

Dosing interval for Nexium

A

1 daily

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25
Dosing interval for esomeprazole
1 daily
26
Strength of Prevacid 24 HR
15mg | OTC
27
Strength of Prevacid (Rx)
30mg
28
Strength of Prevacid SoluTab
15mg | 30mg
29
Generic for PPI associated with SoluTab
lansoprazole
30
Trade name for PPI associated with SoluTab
Prevacid
31
Dosing interval for Prevacid
1 daily
32
Dosing interval for lansoprazole
1 daily
33
Mixture in Dexilant
R isomer of lansoprazole (Prevacid)
34
Dosage form of Dexilant
delayed-release capsule
35
How does dexlansoprazole work?
Dual delayed- release formulation Some is released for immediate relief Rest is released 4 hours later Primarily used for nighttime heartburn(GERD)
36
What PPI would be used for nighttime GERD?
Dexilant (dexlansoprazole)
37
Dosage form of Protonix
delayed-release tablet
38
Dosage form of AcipHex
delayed-release tablet
39
Dosage form of pantoprazole
delayed-release tablet
40
Dosage form of rabeprazole
delayed-release tablet
41
Indications for sulfasalazine
ulcerative colitis | rheumatoid arthritis
42
Indications for Azulfidine
ulcerative colitis | rheumatoid arthritis
43
Dosage forms of sulfasalazine
Tablet - Azulfidine | delayed-release tablet - Azulfidine EnTab
44
Dosage interval for Azulfidine
Three times daily - take with food
45
Dosing interval for Azulfidine EnTab
Three times daily
46
What is mesalamine?
Active component of sulfasalazine (Azulfidine)
47
Indications for mesalamine
ulcerative colitis
48
Dosage form of Asacol
400mg delayed-release tablet
49
Dosage form for Asacol HD
800mg delayed-release tablet
50
Dosage form of Lialda
1.2g delayed-release tablet
51
Dosing interval for Asacol
Three times daily
52
Dosing interval for Asacol HD
Three times daily
53
Dosing interval for Lialda
1 daily
54
Dosage form of Pentasa
250mg or 500mg controlled-release capsule
55
Dosing interval for Pentasa
4 times daily
56
Dosage form of Apriso
0.375g delayed-release/extended-release capsule
57
Dosing interval for Apriso
1 daily
58
Dosage form of Canasa
1g rectal suppository
59
Dosing interval for Canasa
1 daily-Use at bedtime-retain for 1 to 3 hours
60
Dosage form of Rowasa
4g/60ml rectal suspension for enema
61
Dosing interval for Rowasa
1 daily-use at bedtime-retain it for 8 hours(overnight)
62
What is the prokinetic aspect of metaclopramide?
It increases the upper GI tract motility, causing a reduction in heartburn
63
What is a special warning associated with sulfasalazine and mesoalamine?
These drugs are contraindicated for pt's allergic to aspiriin
64
what two therapeutic categories are associated with metoclopramide?
Prokintec/Antiemetic
65
BBW for metoclopramide
Chronic use may cause tardive dyskinesia
66
What is tardive dyskinesia?
Involuntary, repetitive movements
67
Indications for metoclopramide
GERD | nausea/vomiting associated with chemotherapy
68
What is the CTZ?
Chemoreceptor Trigger Zone - Nausea center in the brain
69
WHat is the Antiemetic aspect associated with metoclopramide?
blocks seretonin receptors in the CTZ in teh brain, reducing nausea and vomting.
70
Dosing interval for metoclopramide(Prokinetic)
4 times daily
71
Dosing interval for metoclopramide(Antiemetic)
Take 30 min. before chemotherapy, then every 2 to 3 hours after therapy as needed
72
Dosage forms of metoclopramide
``` tablet (5mg, 10mg) oral solution (5mg/5ml) ```

Drug Info (21 decks)

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