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Flashcards in GI Drug Facts Deck (72):
1

Clinical term for heartburn

gastroesophageal reflux disease

2

What helps the tablet pass through the stomach?

Enteric-coating

3

What is acid-labile?

compound that is destroyed by acid

4

dosage form of Prilosec (Rx)

delayed-release capsule

5

dosage form of omeprazole (Rx)

delayed-release capsule

6

dosage form of Prilosec (OTC)

delayed-release tablet

7

dosage form of omeprazole (OTC)

delayed-release tablet

8

Strengths Prilosec (Rx)

10mg,20mg,40mg

9

Strengths of omeprazole (Rx)

10mg, 20mg, 40mg

10

Indications for PPI's

GERD
erosive esophagitis
gastric ulcers
Zollinger-Ellison Syndrome

11

What is Zollinger-Ellison Syndrome?

A hypersecretory condition where too much gastric acid is produced

12

Dosing interval for PPI's

Take 1 daily, 30 minutes prior to breakfast. Do not take with food-decreases absorption

13

Strength of Prilosec (OTC)

20mg

14

Strength of omeprazole (OTC)

20mg

15

Is Prilosec enteric-coated?

yes

16

What is contained in Zegerid?

NaHCO3 and omeprazole

17

Is Zegerid enteric-coated?

No

18

Strength of Zegerid-OTC

20mg ompeprazole
1100mg NaHCO3

19

Strength of Zegerid (Rx)

40mg omeprazole
1100mg NaHCO3

20

What does the NaHCO3 do?

neutralizes the gastric acid, providing instant heartburn relief and protecting teh omeprazole of acid degradation

21

Strength of Zegerid powder for oral suspension (Rx)

20mg omeprazole
1680mg NaHCO3

40mg omeprazole
1680mg NaHCO3

22

What is the mixture of esomeprazole?

S isomer of omeprazole

23

Composition of Nexium

gel capsule containing enteric coated granules

24

Dosing interval for Nexium

1 daily

25

Dosing interval for esomeprazole

1 daily

26

Strength of Prevacid 24 HR

15mg
OTC

27

Strength of Prevacid (Rx)

30mg

28

Strength of Prevacid SoluTab

15mg
30mg

29

Generic for PPI associated with SoluTab

lansoprazole

30

Trade name for PPI associated with SoluTab

Prevacid

31

Dosing interval for Prevacid

1 daily

32

Dosing interval for lansoprazole

1 daily

33

Mixture in Dexilant

R isomer of lansoprazole (Prevacid)

34

Dosage form of Dexilant

delayed-release capsule

35

How does dexlansoprazole work?

Dual delayed- release formulation
Some is released for immediate relief
Rest is released 4 hours later
Primarily used for nighttime heartburn(GERD)

36

What PPI would be used for nighttime GERD?

Dexilant (dexlansoprazole)

37

Dosage form of Protonix

delayed-release tablet

38

Dosage form of AcipHex

delayed-release tablet

39

Dosage form of pantoprazole

delayed-release tablet

40

Dosage form of rabeprazole

delayed-release tablet

41

Indications for sulfasalazine

ulcerative colitis
rheumatoid arthritis

42

Indications for Azulfidine

ulcerative colitis
rheumatoid arthritis

43

Dosage forms of sulfasalazine

Tablet - Azulfidine
delayed-release tablet - Azulfidine EnTab

44

Dosage interval for Azulfidine

Three times daily - take with food

45

Dosing interval for Azulfidine EnTab

Three times daily

46

What is mesalamine?

Active component of sulfasalazine (Azulfidine)

47

Indications for mesalamine

ulcerative colitis

48

Dosage form of Asacol

400mg delayed-release tablet

49

Dosage form for Asacol HD

800mg delayed-release tablet

50

Dosage form of Lialda

1.2g delayed-release tablet

51

Dosing interval for Asacol

Three times daily

52

Dosing interval for Asacol HD

Three times daily

53

Dosing interval for Lialda

1 daily

54

Dosage form of Pentasa

250mg or 500mg controlled-release capsule

55

Dosing interval for Pentasa

4 times daily

56

Dosage form of Apriso

0.375g delayed-release/extended-release capsule

57

Dosing interval for Apriso

1 daily

58

Dosage form of Canasa

1g rectal suppository

59

Dosing interval for Canasa

1 daily-Use at bedtime-retain for 1 to 3 hours

60

Dosage form of Rowasa

4g/60ml rectal suspension for enema

61

Dosing interval for Rowasa

1 daily-use at bedtime-retain it for 8 hours(overnight)

62

What is the prokinetic aspect of metaclopramide?

It increases the upper GI tract motility, causing a reduction in heartburn

63

What is a special warning associated with sulfasalazine and mesoalamine?

These drugs are contraindicated for pt's allergic to aspiriin

64

what two therapeutic categories are associated with metoclopramide?

Prokintec/Antiemetic

65

BBW for metoclopramide

Chronic use may cause tardive dyskinesia

66

What is tardive dyskinesia?

Involuntary, repetitive movements

67

Indications for metoclopramide

GERD
nausea/vomiting associated with chemotherapy

68

What is the CTZ?

Chemoreceptor Trigger Zone - Nausea center in the brain

69

WHat is the Antiemetic aspect associated with metoclopramide?

blocks seretonin receptors in the CTZ in teh brain, reducing nausea and vomting.

70

Dosing interval for metoclopramide(Prokinetic)

4 times daily

71

Dosing interval for metoclopramide(Antiemetic)

Take 30 min. before chemotherapy, then every 2 to 3 hours after therapy as needed

72

Dosage forms of metoclopramide

tablet (5mg, 10mg)
oral solution (5mg/5ml)