Glomerular disease I Flashcards Preview

Year 2 Renal > Glomerular disease I > Flashcards

Flashcards in Glomerular disease I Deck (18):
1

glomerulonephritis symptoms

- edema (extracellular volume expansion)
- gross hematuria

2

glomerulonephritis signs

- hematuria
- lipiduria
- some proteinuria
- renal failure

3

what are the RBC signs that point to glomerular origin in glomerulonephritis?

- RBC casts
- dysmorphic RBCs (blebs)

4

what are the three major findings on biopsy for asymptomatic hematuria?

- normal
- thin basement membrane nephropathy
- IgA nephropathy

5

how does IgA nephropathy present?

- symptomatic hematuria with proteinuria
- macroscopic hematuria associated with URTI
- henoch-schonlein purpura

6

pathologically, rapidly progressive glomerulonephritis is characterized by the presence of __________****

cellular crescents

7

what makes up the crescents in rapidly progressive glomerulonephritis?

proliferation of parietal epithelial cells

8

what are the 3 broad causes / categories of rapidly progressive glomerulonephritis?

- direct Ig attack
- immune complex deposition
- pauci-immune

9

direct Ig attack in rapidly progressive glomerulonephritis (goodpasture disease) is made up of antibodies against what component? what are the IF findings?

- anti-GBM Abs

- linear deposits of IgG in GBM

10

what is the IF pattern with immune complex deposition in rapidly progressive glomerulonephritis?

granular

11

what is the most common cause of ACUTE glomerulonephritis worldwide?

post infectious glomerulonephritis

12

what is the pathophysiology of post infectious glomerulonephritis?

in situ immune complex formation due to glomerular deposition of strep nephritic antigens

13

what is the EM pattern of post infectious glomerulonephritis?

subepithelial electron dense deposits

14

what are the pulmonary-renal syndromes?

- anti GBM disease (goodpasture)
- systemic vasculitis
- lupus
- other forms of glomerulonephritis

15

what immunoglobins are present in class III/IV lupus nephritis?

IgG
IgA
IgM
C3
C1q

16

what is the "full house" pattern?

the presence of 3 Igs with C3 and C1q, indicating lupus nephritis (class III/IV)

17

what is the C3 level in post infectious glomerulonephritis?

low

18

what condition is normally seen with henoch schonlein purpura?

IgA nephropathy