Pediatric hematuria and proteinuria Flashcards Preview

Year 2 Renal > Pediatric hematuria and proteinuria > Flashcards

Flashcards in Pediatric hematuria and proteinuria Deck (22):
1

laboratory findings in nephrotic syndrome

- reduced plasma protein
- increased cholesterol, TGs, lipoproteins
- decreased serum sodium
- decreased total calcium
- positive urine dipstick protein

2

what are the three histologic types of primary nephrotic syndrome?

- MCNS
- FSGS
- membranous nephropathy

3

what is the most common cause of nephrotic syndrome in children?

minimal change

4

LM and EM for MCNS

- LM: normal
- EM: effacement of epithelial foot processes

5

heroin use
sickle cell
diabetes

what subtype of nephrotic syndrome?

FSGS

6

membranous nephropathy is characterized by diffuse irregular thickening of the ____________

capillary walls

7

subepithelial spike and dome pattern - what subtype of NS?

membranous

8

what are the lab findings in membranoproliferative GS?

- hypocomplementemia
- UA: proteinuria, possible hematuria
- IF: Ig deposits on BM
- EM: BM thickening with double layer tram tracks

9

what are the secondary causes of nephrotic syndrome?****

- infections
- drugs
- malignancies
- other

10

what are the indications for renal biopsy?

at time of diagnosis:
- age over 10
- persistent or gross hematuria
- HTN
- renal insufficiency
- low C3

subsequently
- persistent proteinuria

11

what is the overall treatment for nephrotic syndrome?

- loop or thiazide
- ACEI / ARB
- statins
- pneumococcal vaccine
- vitamin D and calcium supplementation
- low sodium diet

12

what are the lab findings for nephritic syndrome?

- increased BUN
- increased Cr
- UA: hematuria and proteinuria

13

glomerular origin of hematuria?

- dysmorphic RBCs
- RBC casts

14

what are latency periods in pharyngitis and skin infections for PSGN?

- pharyngitis: 1-2 weeks
- skin: 3-6 weeks

15

what are the lab findings in PSGN? what is the EM finding?

- positive throat culture group A strep
- elevated strep Ab titers (ASO)
- decreased C3****
- RBC casts

- EM: bumpy deposits

16

what are the lab findings in henoch schonlein purpura nephritis?

- IgA deposition on purpura biopsy
- increased serum IgA
- nonspecific blood tests
- potential normocytic anemia

17

what is the most common of gross hematuria in adolescents?

IgA nephropathy (berger)

18

what are the lab findings for IgA nephropathy?

- increased serum IgA
- EM: mesangial cell proliferation

19

what is the inheritance for alport?

X linked (incomplete)

20

what are the clinical manifestations of alport syndrome?

- high frequency SN hearing loss
- anterior lenticonus
- kidney failure 2nd or 3rd decade of life

21

what are the lab findings of alport syndrome (UA, EM)?

- UA: RBC casts, hematuria, proteinuria, pyuria
- EM: split basement membrane

22

what is the pathology in benign familmial hematuria?

diffuse thinning of basement membrane