Interstitial and cystic kidney disease Flashcards Preview

Year 2 Renal > Interstitial and cystic kidney disease > Flashcards

Flashcards in Interstitial and cystic kidney disease Deck (19):
1

what is the most severe form of cystic renal dysplasia?

multicystic dysplastic kidney

2

what is the most dangerous complication from ADPKD?

subarachnoid aneurysm

3

who gets screened for aneurysms?

- family history
- normal renal function with PCKD

4

tuberous sclerosis is a systemic disease characterized by multiple ____________

hamartomas

5

what is pathognomonic for tuberous sclerosis? what is the most common finding?

- cortical brain tubers
- angiomyolipomas

6

what are the most common clinical manifestations of VHL?

retinal angiomas and cerebellar hemangiomas

7

what are the manifestations of medullary cystic disease?

- sodium wasting
- anemia
- renal insufficiency

8

what is used to diagnose medullary cystic disease?

- excretory urography
- sonography and CT scan
- open renal biopsy

9

what are the manifestations of medullary sponge kidney?

- gross and microscopic hematuria
- urinary tract infections
- nephrolithiasis

10

what is the pathology in medullary sponge kidney?

- defective urinary solute concentrating ability
- inability to reduce urinary pH to 5.5
- renal tubular acidosis

11

what is the histology in medullary sponge kidney?

- spherical, oval, or irregular enlargement of medullary and inner papillary portions of collecting tubules

12

what are the 3 types of tubulointerstitial injury?

- acute tubular necrosis
- acute interstitial nephritis
- chronic interstitial nephritis

13

what is the classic triad of acute interstitial nephritis?

- low grade fever
- skin rash
- arthralgias

14

what are the lab abnormalities in acute interstitial nephritis?

- elevation in BUN and creatinine
- abnormal UA
- eosinophilia

15

what is the gold standard test for diagnosing acute interstitial nephritis?

biopsy

16

what are the pathological features of acute interstitial nephritis?

- infiltration of inflammatory cells (lymphocytes, PMNs, eosinophils) in interstitium
- edema
- glomeruli and blood vessels are usually spared

17

what drug classes can cause drug induced acute (and chronic) interstitial nephritis?****

- abx
- NSAIDs
- diuretics
- miscellaneous

18

what is the presentation for chronic interstitial nephritis?

- slowly progressing renal insufficiency
- normal or sterile pyuria UA
- mild proteinuria
- HTN and anemia with moderate to advanced disease

19

what are the pathological features of chronic interstitial nephritis?

- atrophy of tubular cells with flattened epithelial cells and tubule dilation
- interstitial fibrosis
- cellular infiltration within the interstitial compartment and between tubules