Flashcards in Interstitial and cystic kidney disease Deck (19):
what is the most severe form of cystic renal dysplasia?
multicystic dysplastic kidney
what is the most dangerous complication from ADPKD?
who gets screened for aneurysms?
- family history
- normal renal function with PCKD
tuberous sclerosis is a systemic disease characterized by multiple ____________
what is pathognomonic for tuberous sclerosis? what is the most common finding?
- cortical brain tubers
what are the most common clinical manifestations of VHL?
retinal angiomas and cerebellar hemangiomas
what are the manifestations of medullary cystic disease?
- sodium wasting
- renal insufficiency
what is used to diagnose medullary cystic disease?
- excretory urography
- sonography and CT scan
- open renal biopsy
what are the manifestations of medullary sponge kidney?
- gross and microscopic hematuria
- urinary tract infections
what is the pathology in medullary sponge kidney?
- defective urinary solute concentrating ability
- inability to reduce urinary pH to 5.5
- renal tubular acidosis
what is the histology in medullary sponge kidney?
- spherical, oval, or irregular enlargement of medullary and inner papillary portions of collecting tubules
what are the 3 types of tubulointerstitial injury?
- acute tubular necrosis
- acute interstitial nephritis
- chronic interstitial nephritis
what is the classic triad of acute interstitial nephritis?
- low grade fever
- skin rash
what are the lab abnormalities in acute interstitial nephritis?
- elevation in BUN and creatinine
- abnormal UA
what is the gold standard test for diagnosing acute interstitial nephritis?
what are the pathological features of acute interstitial nephritis?
- infiltration of inflammatory cells (lymphocytes, PMNs, eosinophils) in interstitium
- glomeruli and blood vessels are usually spared
what drug classes can cause drug induced acute (and chronic) interstitial nephritis?****
what is the presentation for chronic interstitial nephritis?
- slowly progressing renal insufficiency
- normal or sterile pyuria UA
- mild proteinuria
- HTN and anemia with moderate to advanced disease