Glomerular Diseases Part 1 Flashcards
Discuss the pathogenesis of Glomerular diseases
What is the pathogenesis of nephrotic syndrome ?
Outline the pathogenesis of nephrotic syndrome
Describe the pathogenesis of nephritic syndrome
What are the findings of cytokine mediated injury?
What are the findings in antibodies against glomerulus?
Primary damage to basement membrane
Clinically: Nephritic
Ex:
AntiGBM disease
Dense deposit disease
Diagnostic findings:
Antigen-antibody reaction on immunifluorescence
Deposits seen on electron microscopy
What are the findings of Immune complex deposition (in situ or circulating)?
Basement membrane, endothelial cells, and podocytes are primary sites of damage
Clinically: both nephritic & nephrotic
Examples
Post streptococcal GN
• IgA nephropathy • MPGN
• Membranous nephropathy
Findings: Immune complexes seen on electron microscopy (subepithelial, subendothelial, mesangial) and immunofluorescen
Describe ABCA mediated vasculitis
Most damage to endothelial cells
Nephrotic
Ex:
What are the spectrum 9f Glomerular diseases?
C9ntrast proteinuria and hematuria in renal diseases
Describe predominantly nephrotic syndrome
What dos minimal change, focal segmental glomerulosclerosis and membranous nephropathy look like on light microscopy ?
How much can immunifluorescence diagnose 8n nephrotic syndrome?
How can electron microscopy be used to diagnose nephrotic syndrome?
Describe nephritic syndrome
How can microscopy be used to diagnose nephritic syndrome
How can nephritic syndrome be diagnosed via immunifluorescence?
How can electron microscopy be used to diagnose nephritic syndrome?
What are the pulmonary renal syndromes?
How should we approach the Glomerular disease?
