GLP-1 agonist

Question 1

MoA

Answer 1

Binds to and activates GLP-1 receptors to increase insulin secretion
Suppress glucagon secretion
Slows gastric emptying
Prevents weight gain

Question 2

Examples

Answer 2

Exenatide
Albiglutide
Dulaglutide
Liraglutide
Lixisenatide
Semaglutide

Question 3

Side effects

Answer 3

Pancreatitis
Stop if severe, persistent abdominal pain

Question 4

Missed doses

Answer 4

Do not administer AFTER a meal
Inject within one hour of next meal (Lixisenatide)
Continue with next scheduled dose (Exenatide)
Inject within 3 days of next weekly dose (Dulaglutide, Albiglutide, Liraglutide)

Question 5

Pregnancy + Contraception

Answer 5

Use contraception up to 3 months after stopping