Glycolysis/Gluconeogenesis Flashcards Preview

5242 Cell Metabolism 2 > Glycolysis/Gluconeogenesis > Flashcards

Flashcards in Glycolysis/Gluconeogenesis Deck (9)
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1

What are the irreversible enzyme reactions in Glycolysis?

1. Glucose to Glucose 6-P by Hexokinase
2. PFK-1 to convert F6-P to F1,6 BisP
3. Pyruvate Kinase to convert PEP into Pyruvate

2

Pyruvate is turned into acetyl co-A where? By what? How did it get there

In the mitrochondria by a pyruvate transporter. Converted by Pyruvate dehydrogenase Complex (PDC)

3

What products will inhibit the PDC in acetyl-CoA production? What phosphorylation state inhibits it?

ATP, NADH, and Acetyl-CoA. Phosphorylation of complex will inhibit it.

4

What cofactors are required for the conversion of Pyruvate into Acetyl-CoA?

1. Coenzyme A,
2. NAD+,
3. TPP,
4. Lipoic acid,LipoateLipoamide
5. FAD

5

Insulin regulates glycolysis by doing what two things? glycolysis activated or inhibited?

1. Inhibits Fructose 2,6-BisPase, Increasing F 2,6 BisP
2. Dephosphorylates PK, Activating it
-Overall it activates glycolysis

6

Glucagon regulates glycolysis by doing what? Glycolysis activated or inhibited?

Glucagon activates cAMP signaling, which increases PKA, which activates Fructose 2,6-bisPase, reducing Fructose 2,6-BisP. It also Phosphorylates PK, inactivating it. This inhibits glycolysis.

7

Where does anaerobic glycolysis occur?

1. Red blood cells
2. Vigorously working muscles
3. Ischemia
4. Tumors

8

What is the cori cycle? What products from where?

Catablolism of glucose in skeletal/red blood cells into lactate, then anabolism of lactate to glucose in the liver.

9

In beta-Oxidation, what are the resulting molecules?

2 molecules cleaved off for an 1 Acetyl-CoA, an NADH and FADH.