Glycolysis/Gluconeogenesis Flashcards Preview

5242 Cell Metabolism 2 > Glycolysis/Gluconeogenesis > Flashcards

Flashcards in Glycolysis/Gluconeogenesis Deck (9)
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What are the irreversible enzyme reactions in Glycolysis?

1. Glucose to Glucose 6-P by Hexokinase
2. PFK-1 to convert F6-P to F1,6 BisP
3. Pyruvate Kinase to convert PEP into Pyruvate


Pyruvate is turned into acetyl co-A where? By what? How did it get there

In the mitrochondria by a pyruvate transporter. Converted by Pyruvate dehydrogenase Complex (PDC)


What products will inhibit the PDC in acetyl-CoA production? What phosphorylation state inhibits it?

ATP, NADH, and Acetyl-CoA. Phosphorylation of complex will inhibit it.


What cofactors are required for the conversion of Pyruvate into Acetyl-CoA?

1. Coenzyme A,
2. NAD+,
3. TPP,
4. Lipoic acid,LipoateLipoamide
5. FAD


Insulin regulates glycolysis by doing what two things? glycolysis activated or inhibited?

1. Inhibits Fructose 2,6-BisPase, Increasing F 2,6 BisP
2. Dephosphorylates PK, Activating it
-Overall it activates glycolysis


Glucagon regulates glycolysis by doing what? Glycolysis activated or inhibited?

Glucagon activates cAMP signaling, which increases PKA, which activates Fructose 2,6-bisPase, reducing Fructose 2,6-BisP. It also Phosphorylates PK, inactivating it. This inhibits glycolysis.


Where does anaerobic glycolysis occur?

1. Red blood cells
2. Vigorously working muscles
3. Ischemia
4. Tumors


What is the cori cycle? What products from where?

Catablolism of glucose in skeletal/red blood cells into lactate, then anabolism of lactate to glucose in the liver.


In beta-Oxidation, what are the resulting molecules?

2 molecules cleaved off for an 1 Acetyl-CoA, an NADH and FADH.