glycolysis other

Question 1

PFK1 effectors

Answer 1

ATP + citrate reduces

AMP + fructose 2,6 bisphos increases

Question 2

role of PFK2

Answer 2

activator of PFK1 (blocks ATP from binding to allosteric site). The liver is then able to convert excess glu to fat

Question 3

what controls pyruvate kinase

Answer 3

F1,6 biphos activates (signaling glycolosis is happening)

Covelent modification by protein kinase inhibits it

Question 4

Arsenic role

Answer 4

G3P dehydrogenase inhibitor

Question 5

Flouride role

Answer 5

enolase inhibitor

Fl binds to mg so it wont work

Question 6

what molecule stabalizes hemoglobin

Answer 6

2,3 biphoglycerate (from 1-3BPG)

-Biphosphoglyerate mutase

Question 7

Mannose metabolism

Answer 7

trapped (hexokinase)

Mannose 6P to F6P ( Phosphomannose isomerase)

Question 8

Fructose metabolism (in livr)

Answer 8

• trapped by fructokinase
• breaks down to DHAP and glyceraldyhye (aldolase)
• Glyceraldyhde to G3P (triose kinase)

Question 9

Fructose synthesis

Answer 9

1. Sorbitol formed from glu (aldose reductase)

2. Sorbitol -> fructose (sorbitol dehydrogenase)

Question 10

Galactose metabolism

Answer 10

1. Galactokinase traps galactose
2. Uridytransferase transfers phosphate to form glucose 1 phos and UDP galactose
3. UDP glucose epimerase changes UDP galactose to UDP glu
4. Phosphoglucomutate changes G1P to G6P

Question 11

what is deficiant in classical and non classical galactosemia

Answer 11

classical- Galactose 1 P Uridyltransferate

Non classical- Galactose kinase

Question 12

UDP glucose synthesis

Answer 12

phosphorylation (hexokinase)

Phosphoglucomutase move G6p to G1P

UDP glucose pyrophosplorylase uses UTP to add UDP

Question 13

Glycerol Metabolism

Answer 13

1. phosphorylation- gylerol kinase traps glycerol 3P

2. Glycerol 3P dehydrogenase removes H w NAD to form DHAP