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Flashcards in Gut Drugs Deck (14)
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1

What are some common problems encountered with the gut?

- Vomiting
- Diarrhoea
- Ulcers
- Ileus
- Colis
- Constipation
- Bloat

2

How do you treat vomiting?

Give fluids IV to avoid the gut
- water
- H+
- Cl-
- K+
- Na+

Possibly antiemetics

... Treatment depends on cause

- Better to replace fluids than give anti-emetics because it allows the body to expel

3

How do you treat diarrhoea?

Animal will be losing water and ions
Give fluids containing:
- K +
- HCO3-
- water
- Na+
Kidneys can then begin working to bring the body composition back to normal

Motility Reducers
(Antibiotics)
(Anti-inflammatories)
(Wormers)
- all case dependent

4

How do you treat ulcers?

- Proton pump inhibitors - inhibits H+/K+ ATPase in apical parietal cell
- H2 Antagonists : block interactions of secretagogues with receptors = inhibit acid secretion
- Coating agents (artificial mucus)
- Antibiotics
- Anticholinergics
- Prostaglandins

5

How do you treat Colic?

- Analgesics
- Fluids
- Motility reducers
- Antispasmodic

6

How do you treat constipation?

- Fluids by enema
- Laxatives
- (prokinetics)

7

Ways to give fluids for gut problems...

- Oral is best
- IV if necessary
- SC not much use
- IM no use and painful
- Intraperitoneal can be dangerous (hit organs)
- Intraosseous painful and required aseptic high pressure technique

8

What are some antiemetics that can be given?

- Phenothiazines
- Dopamine antagonists
- 5HT3 antagonists
- NK1 antagonists
- (Antihistamines)
- (Anticholinergics)

9

What are some emetics that can be given?

- Apomorphine : not in cats
- Xylazine
- Mustard - home remedy for suspected poisoning
- Saturated salt solutions

10

What can be given to increase gut motility?

- Prokinetics for ileus:
-- metoclopramide
-- erythromycin

- Spasmolytics:
-- anticholinergics
-- opioids

11

When do you give antibiotics when there is a gut problem?

- If there is evidence of bacterial invasion
- A specific pathogen has been cultured

12

Why do you give anti-inflammatories to a problem gut? Examples?

Inflammatory bowel disease (colitis)
- sulphasalazine (BEST)
- olsalazine
- mesalazine

Not usually NSAIDs or steroids

13

What are some different forms of laxatives?

- Enemas
- Bulk forming laxatives
- Osmotic laxatives
- Lubricant laxatives
- Irritant laxatives

14

What do fat pills do?

Blocks the uptake of lipids in the gut and induces a sense of fullness
- For overweight dogs

e.g. dirlotapide