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Flashcards in Haem1 Deck (417)
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391

How dose mesna prevent haemorrhagic cystitis in pts getting cyclophosphamide?

It binds to the urotoxic metabolites produced by cyclophosphamide, which reduces then the incidence of haemorrhagic cystitis

392

T/F? Cyclophosphamide is an alkylating agent?

True. Works by cross-linking DNA.

393

What's the treatment of choice for TTP?

Plasma exchange first-line.

394

Is haemochromatosis inheritance AR or AD?

AR

395

In the general population, what is the most useful marker for screening for haemochromatosis?

Transferrin saturation

396

A liver biopsy is positive for Perl's stain. Diagnosis?

Perl's stain = iron; pt has haemochromatosis

397

What would you expect regarding the following parameters in someone with HH? Transferrin saturation, ferritin, and total iron binding capacity? (low, normal, high)

Transferrin saturation - high

398

With regards to HH, monitoring of what parameter is best to assess adequacy of venesection?

Ferritin

399

What % of pts with MGUS go on to get MM in 5 yrs?

10% at 5 yrs;

400

T/F? B2-microglobulin is a useful marker of prognosis in MM?

True; a raised level implies poor prognosis

401

Reed-Sternberg cells = what diagnosis?

Hodgkin's lymphoma

402

T/F? Hodgkin's lymphoma is commonest in the young (20s) and older ppl (60s)

True

403

What's the Ann-Arbor staging of Hodgkin's lymphoma?

Ann-Arbor staging of Hodgkin's lymphoma

404

What's the most common type of Hodgkin's lymphoma?

Nodular sclerosing

405

Name 3 poor prognostic factors in CLL

Male

406

5-15% of ppl with polylcythemia rubra vera progress to what?

Myelofibrosis or AML

407

What's the management of polycythemia rubra vera?

Venesection - first line treatment

408

What's the best test to screen the gen pop for HH? How about an asymptomatic first degree relative of someone with known HH?

Gen pop = use transferrin saturation (better than ferritin level)

409

Would amiodarone enhance or decrease warfarin's function? (ie increase or decrease INR?)

Increase / enhances warfarin, ie expect an increased INR with concommitant use of warfarin

410

Do people with rheum arthritis get thrombocytosis or thrombocytopenia?

Tend towards thrombocytosis

411

Which haematological malignancy is a/w gingival hyperlasia?

AML

412

Anti-thymocyte globulin (ATG) and anti-lymphocyte globulin (ALG) is used in what condition?

Aplastic anaemia

413

What's the most common bleeding disorder? What's the most common clotting disorder?

Bleeding - vWF

414

T/F? Plasma exchange is first line therapy for ITP

False. First line is a trial of oral PNL; 80% of pts respond. If not responding, do splenectomy, +/- IVIg +/- immunosuppressive drugs

415

What diseases are thymomas associated with?

Thymomas are the most common tumour of the anterior mediastinum

Associated with
myasthenia gravis (30-40% of patients with thymoma)
red cell aplasia
dermatomyositis
also : SLE, SIADH

416

What malignancies are ABV, HTLV-1 and HIV-1 associated with?

EBV: Hodgkin's and Burkitt's lymphoma, nasopharyngeal carcinoma
HTLV-1: Adult T-cell leukaemia/lymphoma
HIV-1: High-grade B-cell lymphoma

417

What are the high and low risk chemotherapeutic agents with regard to infertility?

High - ALKYLATORS
- cyclophosphamide
- chlorambucil
- procarbazine
- melphalan

Low
Antimetabolites
Vincristine
Bleomycin